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Titolo:
MONOCLONAL-ANTIBODIES USED IN THE DETECTION AND TREATMENT OF EPITHELIAL OVARIAN-CANCER
Autore:
MUTO MG; KASSIS AI;
Indirizzi:
HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DEPT OBSTET & GYNECOL,DIV GYNECOL ONCOL,75 FRANCIS ST BOSTON MA 02115 HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DEPT RADIOL,DIV NUCL MED BOSTON MA 02115
Titolo Testata:
Cancer
fascicolo: 10, volume: 76, anno: 1995, supplemento:, S
pagine: 2016 - 2027
SICI:
0008-543X(1995)76:10<2016:MUITDA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-111 CYT-103 IMMUNOSCINTIGRAPHY; HUMAN ANTIMURINE ANTIBODY; PHASE-I TRIAL; INTRAPERITONEAL RADIOIMMUNOTHERAPY; CONJUGATED ANTIBODIES; IMMUNE-RESPONSE; TUMOR UPTAKE; THERAPY; CARCINOMA; INVIVO;
Keywords:
RADIOIMMUNODIAGNOSIS; RADIOIMMUNOTHERAPY; OVARIAN CANCER; MONOCLONAL ANTIBODIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
100
Recensione:
Indirizzi per estratti:
Citazione:
M.G. Muto e A.I. Kassis, "MONOCLONAL-ANTIBODIES USED IN THE DETECTION AND TREATMENT OF EPITHELIAL OVARIAN-CANCER", Cancer, 76(10), 1995, pp. 2016-2027

Abstract

Conventional therapy for epithelial ovarian cancer, including aggressive cytoreductive surgery followed by combination chemotherapy regimens, has failed to reduce the number of deaths caused by this disease, which remains the most lethal of gynecologic malignancies. Monoclonal antibodies, which offer the promise of high selectivity for detection and therapy, may be targeted to tumor-associated antigens, growth factors, receptors, or oncogenes. They may be used alone as immunotherapeutic agents or conjugated to chemotherapeutic drugs, toxins, or radionuclides. Radioimmunoconjugates may also be used for preoperative or intraoperative tumor localization, The authors focused on the clinical utility, technical limitations, and potential of monoclonal antibodies inthe detection and treatment of epithelial ovarian cancer with emphasis on radioimmunodetection and radioimmunotherapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/21 alle ore 15:40:06