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Titolo:
INDUCTION OF THE LIM HOMEOBOX GENE LMX1 BY WNT7A ESTABLISHES DORSOVENTRAL PATTERN IN THE VERTEBRATE LIMB
Autore:
RIDDLE RD; ENSINI M; NELSON C; TSUCHIDA T; JESSELL TM; TABIN C;
Indirizzi:
HARVARD UNIV,SCH MED,DEPT GENET BOSTON MA 02115 COLUMBIA UNIV,HOWARD HUGHES MED INST,DEPT BIOCHEM & MOLEC BIOPHYS NEWYORK NY 10032
Titolo Testata:
Cell
fascicolo: 4, volume: 83, anno: 1995,
pagine: 631 - 640
SICI:
0092-8674(1995)83:4<631:IOTLHG>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ECTODERMAL CONTROL; WINGLESS PROTEIN; IMAGINAL DISKS; INSULIN GENE; CHICK-EMBRYO; DROSOPHILA; EXPRESSION; BUD; DIFFERENTIATION; HOMEODOMAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
R.D. Riddle et al., "INDUCTION OF THE LIM HOMEOBOX GENE LMX1 BY WNT7A ESTABLISHES DORSOVENTRAL PATTERN IN THE VERTEBRATE LIMB", Cell, 83(4), 1995, pp. 631-640

Abstract

During vertebrate limb development, the ectoderm directs the dorsoventral patterning of the underlying mesoderm. To define the molecular events involved in this process, we have analyzed the function of WNT7a,a secreted factor expressed in the dorsal ectoderm, and LMX1, a LIM homeodomain transcription factor expressed in the dorsal mesenchyme. Ectopic expression of Wnt7a is sufficient to induce and maintain Lmx1 expression in limb mesenchyme, both in vivo and in vitro. Ectopic expression of Lmx1 in the ventral mesenchyme is sufficient to generate double-dorsal limbs. Thus, the dorsalization of limb mesoderm appears to involve the WNT7a-mediated induction of Lmx1 in limb mesenchymal cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:32:33