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Titolo:
VARIABILITY IN THE CELL PHENOTYPE OF AGGREGATES OR CLONES OF HUMAN OSTEOARTHRITIC CARTILAGE - A CASE-REPORT
Autore:
KOURI JB; ARGUELLO C; QUINTERO M; CHICO A; RAMOS ME;
Indirizzi:
INST POLITECN NACL,CTR INVEST & ESTUDIOL AVANZADOS,DEPT PATOL EXPT,AVE IPN 2508 MEXICO CITY 07300 DF MEXICO HOSP ANDES,UNIDAD REUMATOL MERIDA VENEZUELA HOSP CLIN QUIRURG HERMANOS AMEIJEIRAS,UNIDAD REUMATOL HAVANA CUBA CTR NACL INVEST CIENT,DEPT MICROSCOPIA ELECT HAVANA CUBA
Titolo Testata:
Biocell
fascicolo: 3, volume: 20, anno: 1996,
pagine: 191 - 200
SICI:
0327-9545(1996)20:3<191:VITCPO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBRONECTIN FRAGMENTS;
Keywords:
OSTEOARTHRITIS; ARTICULAR CARTILAGE; CHONDROCYTES; CYTOSKELETON;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
J.B. Kouri et al., "VARIABILITY IN THE CELL PHENOTYPE OF AGGREGATES OR CLONES OF HUMAN OSTEOARTHRITIC CARTILAGE - A CASE-REPORT", Biocell, 20(3), 1996, pp. 191-200

Abstract

Human samples of articular cartilage from the knee of a clinically classified osteoarthritic patient, assessed by arthroscopy as part of the surgical treatment, was studied by light and transmission electron microscopy. This particular case differed from others already reported in the variability of cell phenotype within the aggregates or ''clones'' frequently present in the osteoarthritic cartilage. The most commonmorphology of ''clonal'' cells forming the aggregates were large and rounded with an euchromatic nucleus. The cytoplasm was characterized by the presence of alternately clear and dense sites. At the ultrastructural level it was seen that the clear sites were formed by disrupted intermediates filaments and small particles, and that the dense sites were constituted by the segregation of different organelles of the chondrocytes. In addition, there were atypical aggregates composed only by secretory cells or by degenerating chondrocytes. Furthermore, a complex structure consisting of a very large cell inside a giant lacunae delimited by electron-dense material with small vesicles is described as a novel finding. The variability in the chondrocyte phenotype of theaggregates described here could be an indication of a better prognosis; nevertheless, the follow-up of the evolution of this patient is needed in order to know the final outcome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 07:10:45