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Titolo:
TEMPORAL PATTERNS OF UNCOUPLING BETWEEN OXIDATIVE-METABOLISM AND REGIONAL CEREBRAL BLOOD-FLOW DEMONSTRATED BY FUNCTIONAL MAGNETIC-RESONANCE-IMAGING
Autore:
HEDERA P; WU D; LEWIN JS; MILLER D; LERNER AJ; FRIEDLAND RP;
Indirizzi:
CASE WESTERN RESERVE UNIV,DEPT NEUROL,11100 EUCLID AVE CLEVELAND OH 44106 UNIV HOSP CLEVELAND,DEPT NEUROL,NEUROGERIATR LAB CLEVELAND OH 00000 UNIV HOSP CLEVELAND,DEPT RADIOL CLEVELAND OH 00000 ST LUKES HOSP,DEPT MED,DIV NEUROL CLEVELAND OH 00000
Titolo Testata:
Investigative radiology
fascicolo: 11, volume: 30, anno: 1995,
pagine: 625 - 633
SICI:
0020-9996(1995)30:11<625:TPOUBO>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN VISUAL-CORTEX; POSITRON EMISSION TOMOGRAPHY; PHOTIC-STIMULATION; PHYSIOLOGICAL STIMULATION; SENSORY STIMULATION; BRAIN OXYGENATION; MOTOR CORTEX; CONTRAST; ACTIVATION; GLUCOSE;
Keywords:
FUNCTIONAL MAGNETIC RESONANCE IMAGING; DEOXYHEMOGLOBIN; OXIDATIVE METABOLISM; VISUAL CORTEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
P. Hedera et al., "TEMPORAL PATTERNS OF UNCOUPLING BETWEEN OXIDATIVE-METABOLISM AND REGIONAL CEREBRAL BLOOD-FLOW DEMONSTRATED BY FUNCTIONAL MAGNETIC-RESONANCE-IMAGING", Investigative radiology, 30(11), 1995, pp. 625-633

Abstract

RATIONALE AND OBJECTIVES Brain activation can be detected by functional magnetic resonance imaging, Termination of stimulation can cause drop of postactivation signal below preactivation baseline; the nature of this ''undershoot'' remains controversial, The authors investigated postactivation signal after stimulation of the visual cortex with photic stimuli of different duration, METHODS. Activation of visual cortexin 11 healthy subjects was studied. The authors underwent short and long stimulation, The relation between activation and postactivation signal was investigated after both durations of stimulation.RESULTS. Average postactivation signal after short stimulation was -1.71 +/- 2.66%and after long stimulation 0.82 +/- 1.59% (P less than or equal to 0.01). Significant ''undershoot'' was detected after short stimulation in the majority of cases, although this was typically absent after longstimulation. CONCLUSIONS The authors propose that ''undershoot'' is caused by decreased oxygen content in venous blood compared with the preactivation level and may reflect increased extraction of oxygen as a result of glycolytic metabolism, The absence of ''undershoot'' after longer stimulation suggests a gradual shift from uncoupling between regional cerebral blood flow and oxygen consumption toward a steady state.

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Documento generato il 24/11/20 alle ore 14:31:02