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Titolo:
BCL-2 ONCOPROTEIN IS WIDESPREAD IN LYMPHOID-TISSUE AND LYMPHOMAS BUT ITS DIFFERENTIAL EXPRESSION IN BENIGN VERSUS MALIGNANT FOLLICLES AND MONOCYTOID B-CELL PROLIFERATIONS IS OF DIAGNOSTIC-VALUE
Autore:
WANG TL; LASOTA J; HANAU CA; MIETTINEN M;
Indirizzi:
THOMAS JEFFERSON UNIV,DEPT PATHOL & CELL BIOL,DIV SURG PATHOL,MAIN BLDG SUITE 263,132 S 10TH ST PHILADELPHIA PA 19107 THOMAS JEFFERSON UNIV,JEFFERSON MED COLL,DEPT ANAT PATHOL & CELL BIOLPHILADELPHIA PA 19107 JEFFERSON CANC INST PHILADELPHIA PA 00000
Titolo Testata:
APMIS. Acta pathologica, microbiologica et immunologica Scandinavica
fascicolo: 9, volume: 103, anno: 1995,
pagine: 655 - 662
SICI:
0903-4641(1995)103:9<655:BOIWIL>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; NON-HODGKINS-LYMPHOMAS; FOLLICULAR HYPERPLASIA; PROTEIN; REARRANGEMENT; BREAKPOINT; TRANSLOCATION; DEATH;
Keywords:
BCL-2; MONOCYTOID B CELL; FOLLICULAR LYMPHOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
T.L. Wang et al., "BCL-2 ONCOPROTEIN IS WIDESPREAD IN LYMPHOID-TISSUE AND LYMPHOMAS BUT ITS DIFFERENTIAL EXPRESSION IN BENIGN VERSUS MALIGNANT FOLLICLES AND MONOCYTOID B-CELL PROLIFERATIONS IS OF DIAGNOSTIC-VALUE", APMIS. Acta pathologica, microbiologica et immunologica Scandinavica, 103(9), 1995, pp. 655-662

Abstract

The distribution of Bcl-2 oncoprotein was studied immunohistochemically in formaldehyde-fixed and paraffin-embedded reactive and neoplasticlymphoid tissue. The potential of Bcl-2 for the differential diagnosis of follicular lesions was emphasized, and the results on follicular lesions were correlated with those of polymerase chain reaction (PCR) assay of the immunoglobulin heavy chain gene rearrangement. In hyperplastic lymphoid tissue, Bcl-2 reactivity was widespread, including germinal center surroundings, scattered cells within the germinal centers,and the T-cell areas in general. Distinctively negative lymphoid populations included the majority of germinal center cells, and the negative staining pattern was maintained in cases of florid hyperplasia. In contrast, follicular lymphoma cells were consistently Bcl-2 positive. The immunohistochemical Bcl-2 reactivity of lymphoma follicles correlated with the clonal PCR amplification pattern of the immunoglobulin heavy chain gene; all Bcl-2-negative hyperplasias revealed a non-clonal pattern. Clusters of monocytoid B cells were Bcl-2 negative, whereas monocytoid B-cell lymphomas and closely related MALT lymphomas were positive. All other small cell non-Hodgkin's lymphomas of B-cell types showed nearly uniform Bcl-2 reactivity, whereas large cell B-cell lymphomas were variably positive (74%). In Hodgkin's cells, Bcl-2 reactivitywas seen in the neoplastic populations of most cases of nodular sclerosis and mixed cellularity types, whereas the L&H and Reed-Sternberg cells in lymphocyte predominance Hodgkin's disease were negative in most cases. Bcl-2 immunohistochemistry thus appears very valuable in the differential diagnosis of follicular hyperplasia and neoplasia, and itmay help to distinguish between reactive and neoplastic monocytoid B cells. However, Bcl-2 immunohistochemistry is not useful in the subtyping of B-cell lymphomas.

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Documento generato il 28/09/20 alle ore 11:47:43