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Titolo:
HISTOCHEMISTRY OF NITRIC-OXIDE SYNTHASE IN THE NERVOUS-SYSTEM
Autore:
BLOTTNER D; GROZDANOVIC Z; GOSSRAU R;
Indirizzi:
FREE UNIV BERLIN,DEPT ANAT,KONIGIN LUISE STR 15 D-14195 BERLIN GERMANY
Titolo Testata:
Histochemical Journal
fascicolo: 10, volume: 27, anno: 1995,
pagine: 785 - 811
SICI:
0018-2214(1995)27:10<785:HONSIT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
NADPH-DIAPHORASE ACTIVITY; DINUCLEOTIDE-PHOSPHATE-DIAPHORASE; RAT SPINAL-CORD; DORSAL-ROOT GANGLIA; GUINEA-PIG HEART; GLUTAMIC-ACID DECARBOXYLASE; SOLUBLE GUANYLYL CYCLASE; MONKEY SAIMIRI-SCIUREUS; CHOLINERGIC NEURONS; MESSENGER-RNA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
270
Recensione:
Indirizzi per estratti:
Citazione:
D. Blottner et al., "HISTOCHEMISTRY OF NITRIC-OXIDE SYNTHASE IN THE NERVOUS-SYSTEM", Histochemical Journal, 27(10), 1995, pp. 785-811

Abstract

Nitric oxide synthase, which generates the physiological messenger molecule nitric oxide, and its associated NADPH diaphorase (NADPHd) activity are distributed throughout selective neuronal populations of the central and peripheral nervous system. Considerable evidence has been accumulated to indicate that NADPHd activity labels cells lacking neuronal nitric oxide synthase, i.e., the specificity of the reaction has to be considered for the reliable detection of the enzyme in neuronal but also non-neuronal tissue. In the present review, critical aspects of nitric oxide synthase visualization in neurones, using its NADPHd activity, are discussed. Furthermore, the organization of the central and peripheral nitric oxide synthase-containing neuronal systems is described. Nitric oxide synthase is present in local cortical and striatal neurones, hypothalamic magnocellular neurones, mesopontine cholinergic neurones, cerebellar intemeurones, preganglionic sympathetic and parasympathetic neurones, neurones in parasympathetic autonomic and enteric ganglia and primary viscero-afferent neurones. Finally, injury-related alterations in nitric oxide synthase activity are briefly outlined. In this respect, the histochemistry of nitric oxide synthase may represent a valuable marker for neurochemical, if not structural, alterations observed in neural diseases, regeneration and transplantation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:31:46