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Titolo:
A ROLE FOR A 70-KDA AMINO-TERMINAL FIBRONECTIN FRAGMENT IN SUPPORTINGSOLUBLE GELATIN INTERACTIONS WITH RAT PERITONEAL-MACROPHAGES
Autore:
PENC SF; BLUMENSTOCK FA; KAPLAN JE;
Indirizzi:
ALBANY MED COLL,DEPT PHYSIOL & CELL BIOL A134 ALBANY NY 12208 ALBANY MED COLL,DEPT PHYSIOL & CELL BIOL A134 ALBANY NY 12208
Titolo Testata:
Journal of leukocyte biology
fascicolo: 5, volume: 58, anno: 1995,
pagine: 501 - 509
SICI:
0741-5400(1995)58:5<501:ARFA7A>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLD-INSOLUBLE GLOBULIN; PLASMA FIBRONECTIN; HUMAN-MONOCYTES; SYNOVIAL-FLUID; COLLAGENOUS DEBRIS; THERMAL-INJURY; BINDING; DEGRADATION; FIBRIN; CELLS;
Keywords:
PLASMA FIBRONECTIN; FIBRONECTIN FRAGMENTS; LIGAND;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
S.F. Penc et al., "A ROLE FOR A 70-KDA AMINO-TERMINAL FIBRONECTIN FRAGMENT IN SUPPORTINGSOLUBLE GELATIN INTERACTIONS WITH RAT PERITONEAL-MACROPHAGES", Journal of leukocyte biology, 58(5), 1995, pp. 501-509

Abstract

Seventy-kilodalton amino-terminal and 180-kDa cell-binding fibronectin fragments were used to determine which fibronectin domains support soluble gelatin interactions with macrophages. At each time measured, intact and 180-kDa fibronectin supported significantly larger quantities of cell-associated gelatin than control levels (P < 0.05), Throughout the time course fibronectin supported more binding than 180 kDa, Seventy kilodalton did not augment gelatin binding until 2 h, but by 6 h 70 kDa supported more binding than intact fibronectin (P < 0.01), Thisappeared to result from a cellular response initiated by 70-kDa-gelatin interactions with the macrophages. Within 4 h the majority of gelatin associated with cells under control conditions, and in the presenceof fibronectin or 180 kDa, was internalized, Seventy-kilodalton-mediated binding remained localized primarily to the cell surfaces at all times, The macrophages partially degraded the internalized and externalgelatin fractions, These results demonstrate that intact fibronectin and specific fibronectin fragments support soluble gelatin interactions with macrophages.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 15:12:41