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Titolo:
PHENCYCLIDINE-INDUCED INCREASES IN STRIATAL NEURON FIRING IN BEHAVINGRATS - REVERSAL BY HALOPERIDOL AND CLOZAPINE
Autore:
WHITE IM; FLORY GS; HOOPER KC; SPECIALE J; BANKS DA; REBEC GV;
Indirizzi:
INDIANA UNIV,DEPT PSYCHOL,PROGRAM NEURAL SCI BLOOMINGTON IN 47405
Titolo Testata:
Journal of neural transmission
fascicolo: 2, volume: 102, anno: 1995,
pagine: 99 - 112
SICI:
0300-9564(1995)102:2<99:PIISNF>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREELY MOVING RATS; AMPHETAMINE-INDUCED EXCITATIONS; INDUCED LOCOMOTOR-ACTIVITY; METHYL-D-ASPARTATE; NUCLEUS-ACCUMBENS; STEREOTYPED BEHAVIOR; INVIVO MICRODIALYSIS; ANTIPSYCHOTIC-DRUGS; NEOSTRIATAL NEURONS; DOPAMINE-RECEPTORS;
Keywords:
STRIATUM; PHENCYCLIDINE; DIZOCILPINE; NEUROLEPTICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
64
Recensione:
Indirizzi per estratti:
Citazione:
I.M. White et al., "PHENCYCLIDINE-INDUCED INCREASES IN STRIATAL NEURON FIRING IN BEHAVINGRATS - REVERSAL BY HALOPERIDOL AND CLOZAPINE", Journal of neural transmission, 102(2), 1995, pp. 99-112

Abstract

Amphetamine and related drugs of abuse facilitate dopamine transmission in the striatum. This action is believed to underlie the increase in firing of striatal motor-related neurons after amphetamine administration in behaving rats. The present study extended this electrophysiological investigation to phencyclidine (PCP), a nonamphetamine psychomotor stimulant that acts primarily as a noncompetitive antagonist of N-methyl-D-aspartate (NMDA) glutamate receptors. Like amphetamine, PCP (1.0, 2.5, or 5.0 mg/kg) increased the activity of striatal motor-related neurons concomitant with behavioral activation. These effects were blocked by subsequent administration of either 1.0 mg/kg haloperidol or 20.0 mg/kg clozapine, typical and atypical neuroleptics, respectively. Dizocilpine (MK-801), another noncompetitive NMDA antagonist, mimicked the effect of PCP. Collectively, these results indicate that amphetamine and NMDA antagonists exert comparable effects on striatal motor-related neurons, suggesting that the response of these cells to psychomotor stimulants is regulated by a dopaminergic-glutamatergic influence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:38:04