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Titolo:
PULMONARY CHEMOREFLEX SENSITIVITY IS ENHANCED BY PROSTAGLANDIN E(2) IN ANESTHETIZED RATS
Autore:
LEE LY; MORTON RF;
Indirizzi:
UNIV KENTUCKY,DEPT PHYSIOL,800 ROSE ST LEXINGTON KY 40536
Titolo Testata:
Journal of applied physiology
fascicolo: 5, volume: 79, anno: 1995,
pagine: 1679 - 1686
SICI:
8750-7587(1995)79:5<1679:PCSIEB>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRONCHIAL REACTIVITY; SENSORY RECEPTORS; HAIRY SKIN; CAPSAICIN; HISTAMINE; REFLEX; MECHANONOCICEPTORS; SENSITIZATION; INFLAMMATION; BRADYKININ;
Keywords:
BRONCHOPULMONARY C FIBERS; CAPSAICIN; PHENYL BIGUANIDE; BRONCHIAL HYPERREACTIVITY; AIRWAY INFLAMMATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
L.Y. Lee e R.F. Morton, "PULMONARY CHEMOREFLEX SENSITIVITY IS ENHANCED BY PROSTAGLANDIN E(2) IN ANESTHETIZED RATS", Journal of applied physiology, 79(5), 1995, pp. 1679-1686

Abstract

Stimulation of vagal pulmonary C-fiber afferents by chemical irritants is believed to be responsible for eliciting the pulmonary chemoreflex (apnea, bradycardia, and hypotension). This study was carried out inanesthetized Sprague-Dawley rats to determine whether the pulmonary chemoreflex was altered by prostaglandin E(2) (PGE(2)), which is one ofthe major inflammatory mediators in the lungs and is known to enhancethe sensitivity of C-fiber afferents in several other organ systems. Capsaicin injected at a dose just above the stimulation threshold (0.25 or 0.5 mu g/kg iv) elicited a very mild respiratory and cardiovascular depression. In sharp contrast, during a constant infusion of PGE(2)(1.5 mu g . kg(-1). min(-1) iv), the same dose of capsaicin triggereda long apnea, with the expiratory duration reaching 843% of the baseline expiratory duration, accompanied by intense bradycardia and hypotension. Similarly, the pulmonary chemoreflex response elicited by a bolus injection of phenyl biguanide (1 or 2 mu g/kg iv) was also greatly augmented by PGE(2). These enhanced responses were completely abolished by a perineural capsaicin treatment of both cervical vagi to selectively block the conduction of C fibers, suggesting the involvement of these afferents. Electrophysiological recording of pulmonary C-fiber afferent activity further supported our conclusion that the sensitivity of these sensory endings to capsaicin challenge was potentiated by PGE(2).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 03:52:00