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Titolo:
MAXIMAL VASODILATION DOES NOT ELIMINATE THE VASCULAR WATERFALL IN THECANINE HINDLIMB
Autore:
SHRIER I; MAGDER S;
Indirizzi:
SIR MORTIMER B DAVIS JEWISH HOSP,HERZL FAMILY PRACTICE CTR,RM E-0010,5757 LEGARE MONTREAL PQ H3T 1Z6 CANADA SIR MORTIMER B DAVIS JEWISH HOSP,LADY DAVIS INST MONTREAL PQ H3T 1Z6 CANADA MCGILL UNIV,MEAKINS CHRISTIE LABS MONTREAL PQ H2X 2N9 CANADA ROYAL VICTORIA HOSP,DIV CRIT CARE MONTREAL PQ H3A 1A1 CANADA
Titolo Testata:
Journal of applied physiology
fascicolo: 5, volume: 79, anno: 1995,
pagine: 1531 - 1539
SICI:
8750-7587(1995)79:5<1531:MVDNET>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRESSURE-FLOW RELATIONSHIPS; ISOLATED SKELETAL-MUSCLE; RESISTANCE; CAPACITANCE; ARTERIOLES; DOG;
Keywords:
CRITICAL PRESSURE; ARTERIAL RESISTANCE; VENOUS RESISTANCE; NITROPRUSSIDE; ADENOSINE; INDOMETHACIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
I. Shrier e S. Magder, "MAXIMAL VASODILATION DOES NOT ELIMINATE THE VASCULAR WATERFALL IN THECANINE HINDLIMB", Journal of applied physiology, 79(5), 1995, pp. 1531-1539

Abstract

Previous studies have shown that blood flow through skeletal muscle is regulated by changes in an arteriolar vascular waterfall [critical pressure (Pcrit)] and a proximal (arterial) resistance (Ra) element. Todetermine whether Pcrit still exists during maximal vasodilation, we pump perfused vascularly isolated canine hindlimbs. We set outflow pressure to zero and measured Pcrit, perfusion pressure (Pper), and regional elastic recoil pressure (Pel; by a stop-flow technique) and calculated both Ra and venous resistance before and after maximal vasodilation with adenosine and nitroprusside. Pcrit was 56.4 +/- 5.1 mmHg before vasodilation and decreased to 11.0 +/- 0.6 mmHg after vasodilation, which was less than the downstream pressure in the venous compliant region (Pel). Therefore, Pcrit should not have affected flow at normal Pper levels under vasodilated conditions. However, we could still measure Pcrit because our technique allowed Pel to decline and Pcrit becomes apparent once Pel < Pcrit. With vasodilation, Ra decreased to <8.1 +/- 2.6% and Rv decreased to 41 +/- 6% of control values. In contrast to the nonvasodilated vasculature, increases in venous pressure during maximal vasodilation caused immediate increases in Pper. This also suggests that the vascular waterfall is inactive under conditions of maximal vasodilation. We conclude that a small arteriolar Pcrit is still present in the maximally vasodilated hindlimb but is less than the downstream pressure and does not affect flow under these conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 16:41:20