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Titolo:
PLATELET ACTIVATION AND INTERACTION WITH LEUKOCYTES IN PATIENTS WITH SEPSIS OR MULTIPLE ORGAN FAILURE
Autore:
GAWAZ M; FATEHMOGHADAM S; PILZ G; GURLAND HJ; WERDAN K;
Indirizzi:
TECH UNIV MUNICH,DEPT MED 1,ISMANINGERSTR 22 D-81675 MUNICH GERMANY TECH UNIV MUNICH,MED KLIN 1 D-81675 MUNICH GERMANY UNIV MUNICH,MED KLIN 1 MUNICH GERMANY
Titolo Testata:
European journal of clinical investigation
fascicolo: 11, volume: 25, anno: 1995,
pagine: 843 - 851
SICI:
0014-2972(1995)25:11<843:PAAIWL>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUTROPHIL INTERACTIONS; APACHE-II; ADHESION; THROMBOSPONDIN; PATHOGENESIS; AGGREGATION; SYSTEM;
Keywords:
FLOW CYTOMETRY; LEUKOCYTE; MEMBRANE GLYCOPROTEINS; MULTIPLE ORGAN FAILURE; PLATELET; SEPSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
M. Gawaz et al., "PLATELET ACTIVATION AND INTERACTION WITH LEUKOCYTES IN PATIENTS WITH SEPSIS OR MULTIPLE ORGAN FAILURE", European journal of clinical investigation, 25(11), 1995, pp. 843-851

Abstract

This study focuses on the role of platelet membrane glycoproteins andplatelet-leucocyte adhesion in patients with sepsis and multiple organ failure (MOF). Specifically, the study raises the following issues: (1) the influence of sepsis and MOF on platelet activation as assessedby surface expression of platelet membrane glycoproteins GPIIb-IIIa and thrombospondin; and (2) the effect of sepsis and MOF on platelet adhesion to circulating leucocytes. In addition, platelet activation andplatelet-leucocyte adhesion are evaluated according to clinical outcome. Forty-five patients with suspected sepsis or MOF were evaluated byintensive care scoring systems (APACHE II and Elebute) to assess severity of disease. Flow cytometric techniques were used to examine platelet membrane expression of various adhesion molecules on circulating platelets and the appearance of platelet specific antigen (CD41) on leucocytes as an index of platelet-leucocyte adhesion. The results were compared with severity of disease and according to outcome in patients. Twenty-eight patients of the total study population were septic and 17 were non-septic. Twenty-two of the 28 septic patients suffered from severe MOF (APACHE II greater than or equal to 20) whereas in six septic patients MOF was absent. Eleven of the non-septic group suffered from moderate MOF whereas in six, severe MOF was present. In septic patients fibrinogen receptor activity on platelets was significantly abovenormal values (P < 0.001). When MOF was present, thrombospondin surface expression on circulating platelets also increased significantly (P< 0.05). Concomitantly, platelet-leucocyte adhesion was increased in sepsis (P < 0.05) and decreased in patients with MOF (P < 0.05). Significant lower levels of circulating platelet-leucocyte aggregates occurred in non-survivors (P < 0.05). We conclude that sepsis is associatedwith increased surface expression of platelet adhesion molecules and an increased occurrence of circulating platelet-leucocyte aggregates. The decrease in circulating platelet-leucocyte aggregates in MOF mightresult from enhanced peripheral sequestration. An increased platelet-leucocyte adhesion and sequestration might account for development of MOF in the course of sepsis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 14:04:30