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Titolo:
CHRONIC MILD STRESS-INDUCED ANHEDONIA MODEL OF DEPRESSION - SLEEP ABNORMALITIES AND CURATIVE EFFECTS OF ELECTROSHOCK TREATMENT
Autore:
MOREAU JL; SCHERSCHLICHT R; JENCK F; MARTIN JR;
Indirizzi:
F HOFFMANN LA ROCHE & CO LTD,PRECLIN CNS RES,DIV PHARMA CH-4002 BASELSWITZERLAND
Titolo Testata:
Behavioural pharmacology
fascicolo: 7, volume: 6, anno: 1995,
pagine: 682 - 687
SICI:
0955-8810(1995)6:7<682:CMSAMO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANIMAL-MODEL; LIFE EVENTS; ANTIDEPRESSANT; DISORDER; PREFERENCE; BEHAVIOR; REVERSAL; ILLNESS;
Keywords:
ANHEDONIA; CHRONIC MILD STRESS; DEPRESSION; ELECTROSHOCK; MODEL; RAT; REM SLEEP; SELF-STIMULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Moreau et al., "CHRONIC MILD STRESS-INDUCED ANHEDONIA MODEL OF DEPRESSION - SLEEP ABNORMALITIES AND CURATIVE EFFECTS OF ELECTROSHOCK TREATMENT", Behavioural pharmacology, 6(7), 1995, pp. 682-687

Abstract

A core symptom of human depressive disorder is anhedonia, the toss ofinterest or pleasure in daily activities. Anhedonia, measured as subsensitivity to reward, can be induced in rats by a regimen of repeated,mild, unpredictable stressors. Here, the hedonic state of rats was assessed using an intracranial self-stimulation (ICSS) procedure. The ICSS frequency threshold was determined before, during and after a period of exposure to the stress regimen. After 13 days of repeated mild stress, the ICSS threshold was significantly increased, suggesting a gradual decrease of sensitivity to reward. This anhedonic state lasted throughout the stress period. When stressed anhedonic animals were givenelectroshock treatment, the stress-induced increase in ICSS thresholdwas rapidly and completely reversed. Moreover, biological markers of human depression such as reduced latency to the first REM sleep episode or increased time spent in REM sleep were also found in electroencephalographic recordings of chronically stressed animals. These sleep abnormalities were observed beginning in the second week of a three-weekstress regimen and progressively disappeared after termination of stress. In conclusion, these data provide further evidence supporting stress-induced anhedonia in rats as a unique animal model of human depression combining convergent elements of biological, etiological, symptomatological and therapeutic validity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:35:22