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Titolo:
FUNCTIONAL EXPLANATION FOR INCREASED ATRIAL-NATRIURETIC-PEPTIDE IN SYSTEMIC-SCLEROSIS
Autore:
KAZZAM E; CAIDAHL K; HEDNER T; WALDENSTROM A;
Indirizzi:
UNIV UMEA HOSP,DEPT INTERNAL MED S-90185 UMEA SWEDEN UNIV UPPSALA HOSP,DEPT INTERNAL MED S-75185 UPPSALA SWEDEN SAHLGRENS UNIV HOSP,DEPT CLIN PHYSIOL S-41345 GOTHENBURG SWEDEN SAHLGRENS UNIV HOSP,DEPT CLIN PHARMACOL S-41345 GOTHENBURG SWEDEN
Titolo Testata:
Clinical cardiology
fascicolo: 11, volume: 18, anno: 1995,
pagine: 647 - 652
SICI:
0160-9289(1995)18:11<647:FEFIAI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGESTIVE HEART-FAILURE; VENTRICULAR DIASTOLIC FUNCTION; DILATED CARDIOMYOPATHY; MESSENGER-RNA; NONINVASIVE ASSESSMENT; POLYPEPTIDE ANP; PLASMA-LEVELS; PRESSURE; SECRETION; EXPRESSION;
Keywords:
ATRIAL NATRIURETIC PEPTIDE; APEXCARDIOGRAM; DIASTOLIC FUNCTION; ECHOCARDIOGRAPHY; LEFT VENTRICLE; SYSTEMIC SCLEROSIS; SYSTOLIC FUNCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
E. Kazzam et al., "FUNCTIONAL EXPLANATION FOR INCREASED ATRIAL-NATRIURETIC-PEPTIDE IN SYSTEMIC-SCLEROSIS", Clinical cardiology, 18(11), 1995, pp. 647-652

Abstract

We related atrial natriuretic peptide (ANP) among 30 consecutive patients with systemic sclerosis (SScl) and 48 gender- and age-matched controls to the measurements of left ventricular CW) function as evaluated by echocardiography and external pulse curves to determine possible causative factors for an increased Ir:vel of plasma ANP. The patients had a markedly elevated plasma ANP level (239.4 +/- 59 vs. 178.2 +/- 36 pmol/l, p < 0.0005), which was not related to LV systolic function, heart rate, or blood pressure. Patients had LV hypertrophy and plasma ANP correlated directly to interventricular septal thickness (r = 0.41, p < 0.005), LV posterior wall thickness (r = 0.32, p < 0.01), and wall thickness to cavity dimension (r= 0.44, p < 0.0005), LV mass index (r = 0.40, p < 0.005). LV early filling properties were impaired, withreduction of atrial emptying index (p < 0.0005) and increased contribution of atrial contraction to LV filling. Plasma ANP correlated to atrial emptying index (r = 0.41, p < 0.0005) and to apex-cardiographic awave (r =: 0.28, p < 0.05). Plasma ANP was also related to left atrial dimension index (r = 0.27, p < 0.05), and was still related to atrial emptying index, but not to left atrial dimension, when considering the degree of LV hypertrophy in multivariate analysis. We conclude thatANP is elevated in patients with SScl. Reduced LV compliance, probably due to increased fibrosis, may cause changes in atrial pressure sufficient to stimulate ANP production without systolic dysfunction as a prerequisite.

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Documento generato il 27/11/20 alle ore 02:10:04