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Titolo:
DETERMINATION OF TOTAL AND HERPES-SIMPLEX VIRUS-SPECIFIC MONOMERIC AND DIMERIC IGA IN SERUM AND CEREBROSPINAL-FLUID BY ULTRACENTRIFUGATION
Autore:
OHMAN S; ERNERUDH J; ROBERG M; FORSBERG P;
Indirizzi:
LINKOPING UNIV HOSP,FAC HLTH SCI,DEPT CLIN CHEM S-58185 LINKOPING SWEDEN LINKOPING UNIV HOSP,FAC HLTH SCI,DEPT CLIN IMMUNOL & TRANSFUS MED S-58185 LINKOPING SWEDEN LINKOPING UNIV HOSP,FAC HLTH SCI,DEPT NEUROL S-58185 LINKOPING SWEDEN LINKOPING UNIV HOSP,FAC HLTH SCI,DEPT INFECT DIS S-58185 LINKOPING SWEDEN
Titolo Testata:
Annals of clinical biochemistry
, volume: 32, anno: 1995,
parte:, 6
pagine: 550 - 556
SICI:
0004-5632(1995)32:<550:DOTAHV>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOGLOBULIN-A IGA; IMMUNE-RESPONSE; ENCEPHALITIS; ANTIBODIES; BARRIER; SYSTEM; SIZE;
Keywords:
IMMUNE COMPLEXES; IGA INDEX; MUCOSA-ASSOCIATED LYMPHOID TISSUE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
S. Ohman et al., "DETERMINATION OF TOTAL AND HERPES-SIMPLEX VIRUS-SPECIFIC MONOMERIC AND DIMERIC IGA IN SERUM AND CEREBROSPINAL-FLUID BY ULTRACENTRIFUGATION", Annals of clinical biochemistry, 32, 1995, pp. 550-556

Abstract

An improved method is described for differentiating between monomericand dimeric total and herpes simplex virus (HSV) specific IgA by ultracentrifugation in sucrose gradient, using recovery and quantitative analysis of the fractions obtained. Calculation of monomeric and dimeric IgA was based on IgG as an internal standard. Intrathecally producedmonomeric and dimeric IgA were judged by calculating IgA indices for each form. A new type of formula indicating relative over-production of dimeric compared with monomeric IgA (IgA dimeric-monomeric index) issuggested. The method was applied to serum and cerebrospinal fluid (CSF) from three patients with HSV encephalitis. The index for monomericas well as dimeric IgA was high during the acute phase of the disease, indicating intrathecal synthesis of both molecular forms. One year after onset, there was no detectable HSV-specific IgA in CSF: both molecular forms, however, remained in serum. The amount of dimeric compared with monomeric IgA was high during the acute phase, and subsequentlydecreased after successful treatment. A new finding was the detectionof HSV-specific IgA heavier than dimeric IgA in serum one year after onset of the disease. These components may be tetrameric IgA, or immune complexes containing IgA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 18:07:40