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Titolo:
EFFICACY OF AZITHROMYCIN AND RIFABUTIN IN PREVENTING INFECTION BY MYCOBACTERIUM-AVIUM COMPLEX IN BEIGE MICE
Autore:
BERMUDEZ LE; PETROFSKY M; INDERLIED CB; YOUNG LS;
Indirizzi:
CALIF PACIFIC MED CTR,KUZELL INST ARTHRITIS & INFECT DIS,RES INST SANFRANCISCO CA 94115 CHILDRENS HOSP LOS ANGELES,DEPT PATHOL & LAB MED LOS ANGELES CA 90027
Titolo Testata:
Journal of antimicrobial chemotherapy
fascicolo: 4, volume: 36, anno: 1995,
pagine: 641 - 646
SICI:
0305-7453(1995)36:4<641:EOAARI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACQUIRED-IMMUNODEFICIENCY-SYNDROME; INTRACELLULARE; PROPHYLAXIS; INVITRO; VIRUS; AIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
L.E. Bermudez et al., "EFFICACY OF AZITHROMYCIN AND RIFABUTIN IN PREVENTING INFECTION BY MYCOBACTERIUM-AVIUM COMPLEX IN BEIGE MICE", Journal of antimicrobial chemotherapy, 36(4), 1995, pp. 641-646

Abstract

We investigated the potential of the azalide, azithromycin, and rifabutin in preventing disseminated infection due to Mycobacterium avium complex (MAC) in beige mice. Azithromycin 200 mg/kg, rifabutin (30 mg/kg or 60 mg/kg) were administered by gavage 6 days before mice were challenged orally with 10(8) cfu MAC and daily for 10 days thereafter during which time the mice were again challenged with the same inoculum on alternate days (days +1, +3, +5, +7, and +9). Sixty-four days later,the presence of bacteria in the blood and the number of viable bacteria in liver, spleen and appendix were estimated. Treatment with azithromycin and 60 mg/kg/day rifabutin but not 30 mg/kg/day, significantly decreased the incidence of bacteraemia and the number of bacteria in the appendix. The administration of azithromycin resulted in significantly fewer MAC in the liver and spleen but not in the appendix whereas the converse was true of 60 mg/kg rifabutin. Our results indicate thatboth azithromycin and rifabutin can prevent MAC disseminated infection, but that the azalide is more effective than the rifamycin in reducing the burden of infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 06:17:41