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Titolo:
INFLUENZA-A PNEUMONITIS FOLLOWING TREATMENT OF ACUTE CARDIAC ALLOGRAFT-REJECTION WITH MURINE MONOCLONAL ANTI-CD3 ANTIBODY (OKT3)
Autore:
EMBREY RP; GEIST LJ;
Indirizzi:
VIRGINIA COMMONWEALTH UNIV MED COLL VIRGINIA,DEPT SURG,DIV CARDIOTHORAC SURG,POB 980068 RICHMOND VA 23298 UNIV IOWA,COLL MED,DIV CARDIOTHORAC SURG IOWA CITY IA 00000 UNIV IOWA,COLL MED,DIV PULM MED IOWA CITY IA 00000
Titolo Testata:
Chest
fascicolo: 5, volume: 108, anno: 1995,
pagine: 1456 - 1459
SICI:
0012-3692(1995)108:5<1456:IPFTOA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIRUS-INFECTION; CELLS;
Keywords:
CARDIAC TRANSPLANTATION; INFLUENZA A; IMMUNO-SUPPRESSION; OKT3;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
R.P. Embrey e L.J. Geist, "INFLUENZA-A PNEUMONITIS FOLLOWING TREATMENT OF ACUTE CARDIAC ALLOGRAFT-REJECTION WITH MURINE MONOCLONAL ANTI-CD3 ANTIBODY (OKT3)", Chest, 108(5), 1995, pp. 1456-1459

Abstract

A 51-year old man developed fever, cough, and dyspnea 5 days after completing murine monoclonal anti-CD3 antibody (OKT3) treatment for acute cardiac allograft rejection. Samples of BAL fluid grew influenza A virus. Progressive pulmonary infiltrates, respiratory compromise, and hypoxia developed, and the patient ultimately required 5 days of mechanical ventilation. Treatment with amantadine hydrochloride and ribavirin was prescribed, and the patient was discharged after 19 days. Influenza A virus has not been an important pathogen in cardiac transplant recipients. However, this is the first reported case of influenza A pneumonitis complicating anti-T lymphocyte therapy for cardiac allograft rejection. In comparison with our patient, two previously reported cases of influenza A infection in cardiac transplant patients have been less severe. The virulence of our patient's, life-threatening infectionappears to be secondary to impairment of T lymphocyte-mediated immunity by OKT3. The role of therapeutic and even prophylactic amantadine therapy in this clinical setting has yet to be determined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:38:13