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Titolo:
COMPARISON BETWEEN THE EFFECTS OF TAMOXIFEN AND TOREMIFENE ON THE UTERUS IN POSTMENOPAUSAL BREAST-CANCER PATIENTS
Autore:
TOMAS E; KAUPPILA A; BLANCO G; APAJASARKKINEN M; LAATIKAINEN T;
Indirizzi:
UNIV OULU,DEPT OBSTET & GYNECOL SF-90220 OULU FINLAND UNIV OULU,DEPT ONCOL SF-90220 OULU FINLAND UNIV OULU,DEPT PATHOL SF-90220 OULU FINLAND
Titolo Testata:
Gynecologic oncology
fascicolo: 2, volume: 59, anno: 1995,
pagine: 261 - 266
SICI:
0090-8258(1995)59:2<261:CBTEOT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PATIENTS RECEIVING TAMOXIFEN; TRIPHENYLETHYLENE COMPOUND; ENDOMETRIAL THICKNESS; WOMEN; THERAPY; ULTRASONOGRAPHY; FC-1157A; POLYPS; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
E. Tomas et al., "COMPARISON BETWEEN THE EFFECTS OF TAMOXIFEN AND TOREMIFENE ON THE UTERUS IN POSTMENOPAUSAL BREAST-CANCER PATIENTS", Gynecologic oncology, 59(2), 1995, pp. 261-266

Abstract

Antiestrogens have been widely used in the treatment of breast cancerpatients. We wanted to compare the uteral and vaginal effects of tamoxifen to those of toremifene. Thirty-one gynecologically asymptomatic postmenopausal breast cancer patients with an intact uterus were randomized to receive 20 mg of tamoxifen (N = 16) or 60 mg of toremifene (N= 15) as an adjuvant treatment. Gynecological examination with vaginal ultrasonography, Pap smear, endometrial biopsy, hysteroscopy, and curettage was performed before the treatment, and at 6 and 12 months of treatment. Endometrial thickness was found to increase significantly during the treatment to the same extent in both groups. Proliferation or other estrogenic effects in the endometrium were observed in 8 of 14patients in the tamoxifen group and in 3 of 10 patients in the toremifene group. Three polyps occurred and previously present uterine fibroids increased in size in 3 of 10 patients during the study. Estrogenicchanges in Pap smear were observed in all patients. There was no significant difference between tamoxifen and toremifene in any of the parameters investigated. Our results suggest that tamoxifen and toremifeneproduce comparable estrogenic effects in the uterus and vagina. (C) 1995 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 04:27:16