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Titolo:
A GONADOTROPIN DEPENDENT STROMAL LUTEOMA - A RARE CAUSE OF POSTMENOPAUSAL VIRILIZATION
Autore:
CHICO A; GARCIA JL; MATIASGUIU X; WEBB SM; RODRIGUEZ J; PRAT J; CALAF J;
Indirizzi:
UNIV AUTONOMA BARCELONA,HOSP SANTA CRUZ & SAN PABLO,DEPT ENDOCRINOL,SERV ENDOCRINOL E-08025 BARCELONA SPAIN UNIV AUTONOMA BARCELONA,HOSP SANTA CRUZ & SAN PABLO,DEPT ENDOCRINOL,SERV ENDOCRINOL E-08025 BARCELONA SPAIN UNIV AUTONOMA BARCELONA,HOSP SANTA CRUZ & SAN PABLO,DEPT GYNECOL E-08025 BARCELONA SPAIN UNIV AUTONOMA BARCELONA,HOSP SANTA CRUZ & SAN PABLO,DEPT PATHOL E-08025 BARCELONA SPAIN UNIV AUTONOMA BARCELONA,HOSP SANTA CRUZ & SAN PABLO,DEPT BIOCHEM E-08025 BARCELONA SPAIN
Titolo Testata:
Clinical endocrinology
fascicolo: 5, volume: 43, anno: 1995,
pagine: 645 - 649
SICI:
0300-0664(1995)43:5<645:AGDSL->2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLINICOPATHOLOGICAL ANALYSIS; OVARIAN TUMOR; HYPERANDROGENISM; SUPPRESSION; CELLS;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
A. Chico et al., "A GONADOTROPIN DEPENDENT STROMAL LUTEOMA - A RARE CAUSE OF POSTMENOPAUSAL VIRILIZATION", Clinical endocrinology, 43(5), 1995, pp. 645-649

Abstract

A stromal luteoma is an uncommon ovarian tumour in post-menopausal women, which presents rarely with hyperandrogenism and virilization. We present the case of a 64-year-old woman referred for evaluation of virilization which had developed over 5 years. Testosterone, FSH and LH were markedly inhibited following the administration of a GnRH analogue, suggesting a gonadotrophin dependent, testosterone secreting ovariantumour, which could not be localized with imaging techniques. Surgeryrevealed normal sized ovaries with no apparent lesions, but microscopic examination showed a small stromal luteoma in the right ovary and severe stromal hyperthecosis in the adjacent and contralateral ovarian stroma. We conclude that stromal luteoma is an uncommon cause of virilization in postmenopausal women. This case illustrates, to our knowledge for the first time, that a stromal luteoma is not autonomous but isgonadotrophin dependent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:07:00