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Titolo: IDENTIFICATION OF DENDRITIC CELLS AS A MAJOR SOURCE OF INTERLEUKIN-6 IN DRAINING LYMPH-NODES FOLLOWING SKIN SENSITIZATION OF MICE
Autore: HOPE JC; CUMBERBATCH M; FIELDING I; DEARMAN RJ; KIMBER I; HOPKINS SJ;
- Indirizzi:
- UNIV MANCHESTER,HOPE HOSP,CTR RHEUMAT DIS SALFORD M6 8HD LANCS ENGLAND ZENECA CENT TOXICOL LAB MACCLESFIELD CHESHIRE ENGLAND
- Titolo Testata:
- Immunology
fascicolo: 3,
volume: 86,
anno: 1995,
pagine: 441 - 447
- SICI:
- 0019-2805(1995)86:3<441:IODCAA>2.0.ZU;2-X
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- LANGERHANS CELLS; FLUORESCEIN ISOTHIOCYANATE; MONOCLONAL-ANTIBODY; LYMPHOCYTES-T; ANTIGEN; PROLIFERATION;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Science Citation Index Expanded
- Citazioni:
- 29
- Recensione:
- Indirizzi per estratti:
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- Citazione:
- J.C. Hope et al., "IDENTIFICATION OF DENDRITIC CELLS AS A MAJOR SOURCE OF INTERLEUKIN-6 IN DRAINING LYMPH-NODES FOLLOWING SKIN SENSITIZATION OF MICE", Immunology, 86(3), 1995, pp. 441-447
Abstract
Skin sensitization with chemical allergens is associated with the activation and proliferation of T lymphocytes within lymph nodes drainingthe site of exposure. These events are accompanied by the secretion of interleukin-6 (IL-6) by lymph node cells (LNC). We have investigatedthe cellular source of IL-6 seventy-two hours following primary exposure of mice to the contact allergen oxazolone. Immunoeytochemical analyses of sections of activated lymph nodes have revealed that cells expressing IL-6 are located within the T-dependent lymph node paracortex,with none present in lymphoid follicles. Cells which expressed IL-6 cofractionated exclusively with LNC of low buoyant density, the majority of which also expressed membrane Ia and had a dendritic morphology. Depletion of dendritic cells from LNC culture was associated with a significant decrease in the secretion of IL-6 by the residual population. These data demonstrate that dendritic cells are a major source of IL-6 within lymph nodes during primary immune responses to cutaneous antigens.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 05:39:49