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Titolo:
IDENTIFICATION OF DENDRITIC CELLS AS A MAJOR SOURCE OF INTERLEUKIN-6 IN DRAINING LYMPH-NODES FOLLOWING SKIN SENSITIZATION OF MICE
Autore:
HOPE JC; CUMBERBATCH M; FIELDING I; DEARMAN RJ; KIMBER I; HOPKINS SJ;
Indirizzi:
UNIV MANCHESTER,HOPE HOSP,CTR RHEUMAT DIS SALFORD M6 8HD LANCS ENGLAND ZENECA CENT TOXICOL LAB MACCLESFIELD CHESHIRE ENGLAND
Titolo Testata:
Immunology
fascicolo: 3, volume: 86, anno: 1995,
pagine: 441 - 447
SICI:
0019-2805(1995)86:3<441:IODCAA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
LANGERHANS CELLS; FLUORESCEIN ISOTHIOCYANATE; MONOCLONAL-ANTIBODY; LYMPHOCYTES-T; ANTIGEN; PROLIFERATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
J.C. Hope et al., "IDENTIFICATION OF DENDRITIC CELLS AS A MAJOR SOURCE OF INTERLEUKIN-6 IN DRAINING LYMPH-NODES FOLLOWING SKIN SENSITIZATION OF MICE", Immunology, 86(3), 1995, pp. 441-447

Abstract

Skin sensitization with chemical allergens is associated with the activation and proliferation of T lymphocytes within lymph nodes drainingthe site of exposure. These events are accompanied by the secretion of interleukin-6 (IL-6) by lymph node cells (LNC). We have investigatedthe cellular source of IL-6 seventy-two hours following primary exposure of mice to the contact allergen oxazolone. Immunoeytochemical analyses of sections of activated lymph nodes have revealed that cells expressing IL-6 are located within the T-dependent lymph node paracortex,with none present in lymphoid follicles. Cells which expressed IL-6 cofractionated exclusively with LNC of low buoyant density, the majority of which also expressed membrane Ia and had a dendritic morphology. Depletion of dendritic cells from LNC culture was associated with a significant decrease in the secretion of IL-6 by the residual population. These data demonstrate that dendritic cells are a major source of IL-6 within lymph nodes during primary immune responses to cutaneous antigens.

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Documento generato il 03/12/20 alle ore 05:39:49