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Titolo:
ARTERIOVENOUS DIFFERENCES IN PLASMA-CONCENTRATIONS OF CATECHOLS IN RATS WITH NEUROPATHIC PAIN
Autore:
RAJA SN; CHOI Y; ASANO Y; HOLMES C; GOLDSTEIN DS;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,DEPT ANESTHESIOL & CRIT CARE MED,600 N WOLFE ST BALTIMORE MD 21287 NINCDS,CLIN NEUROSCI BRANCH BETHESDA MD 00000 NINCDS,CLIN NEUROCHEM SECT BETHESDA MD 00000
Titolo Testata:
Anesthesiology
fascicolo: 5, volume: 83, anno: 1995,
pagine: 1000 - 1008
SICI:
0003-3022(1995)83:5<1000:ADIPOC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
REFLEX SYMPATHETIC DYSTROPHY; SCIATIC-NERVE INJURY; PERIPHERAL NEUROPATHY; BLOOD-FLOW; NOREPINEPHRINE; MODEL; NORADRENALINE; 3,4-DIHYDROXYPHENYLALANINE; INNERVATION; DISORDERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
S.N. Raja et al., "ARTERIOVENOUS DIFFERENCES IN PLASMA-CONCENTRATIONS OF CATECHOLS IN RATS WITH NEUROPATHIC PAIN", Anesthesiology, 83(5), 1995, pp. 1000-1008

Abstract

Background: Alterations in cutaneous temperature, sweating, and cutaneous blood now in patients with pain states, such as reflex sympathetic dystrophy and causalgia, have been interpreted as evidence for exaggerated sympathetic outflow, It was determined whether pain behavior ina rat model of sympathetically maintained pain is associated with alterations in regional sympathoneural function, Methods: Peripheral neuropathy was induced in 29 Sprague-Dawley rats by ligation of the left L5 and L6 spinal nerves, Sixteen other rats had sham surgery (nerve exposure without ligation). Animals were tested for behavioral signs of allodynia (decreased paw withdrawal thresholds to mechanical stimuli) at 2 and 4 weeks after the surgery. Arterial and iliac venous blood samples (left, affected; right, control) were obtained at 2 weeks (NP2, n= 14) and 4 weeks (NP4, n = 15) after neuropathic or sham (n = 8 at 2and 4 weeks) surgery. Plasma concentrations of dihydroxyphenylalanine, dihydroxyphenylacetic acid, dopamine, norepinephrine, and the intraneuronal norepinephrine metabolite, 3,4-dihydroxyphenylglycol, were analyzed in arterial and left and right iliac venous samples, Results: A decrease in paw withdrawal threshold was observed in neuropathic (NP2 and NP4) but not sham-operated rats, Affected and control Limbs did not differ in arteriovenous differences in concentrations of dihydroxyphenylalanine, dihydroxyphenylacetic acid, dopamine, or 3,4-dihydroxyphenylglycol. No differences were observed between sham-operated and neuropathic animals in these arteriovenous increments. In contrast, affected Limbs of NP2 rats had a reduced arteriovenous increment in norepinephrine concentrations, compared to that in the control side (P < 0.05). Conclusions: No neurochemical evidence of sympathetic hyperactivity is observed in the rat model of neuropathic pain; if anything, norepinephrine release is decreased in the affected limb. Autonomic disturbances in neuropathic pain are therefore more likely the result of receptor supersensitivity than increased local sympathoneural traffic.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 03:33:25