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Titolo:
SEPSIS-INDUCED ACUTE LUNG INJURY IS ATTENUATED BY SELECTIN BLOCKADE FOLLOWING THE ONSET OF SEPSIS
Autore:
RIDINGS PC; BLOOMFIELD GL; HOLLOWAY S; WINDSOR ACJ; JUTILA MA; FOWLER AA; SUGERMAN HJ;
Indirizzi:
VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT SURG,BOX 980519,MCVSTN RICHMOND VA 23298 VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT SURG RICHMOND VA 23298 VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PEDIAT RICHMOND VA 23298 VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT MED RICHMOND VA 23298 MONTANA STATE UNIV,DEPT VET MOLEC BIOL BOZEMAN MT 59717
Titolo Testata:
Archives of surgery
fascicolo: 11, volume: 130, anno: 1995,
pagine: 1199 - 1208
SICI:
0004-0010(1995)130:11<1199:SALIIA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; TUMOR-NECROSIS-FACTOR; LEUKOCYTE ADHESION MOLECULE-1; GRAM-NEGATIVE SEPSIS; NEUTROPHIL ADHESION; CARBOHYDRATE LIGAND; CELL-ADHESION; TISSUE-INJURY; P-SELECTIN; IN-VIVO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
P.C. Ridings et al., "SEPSIS-INDUCED ACUTE LUNG INJURY IS ATTENUATED BY SELECTIN BLOCKADE FOLLOWING THE ONSET OF SEPSIS", Archives of surgery, 130(11), 1995, pp. 1199-1208

Abstract

Objective: To determine the effect of infusion with a dual-binding antibody to E- and L-selectin, EL-246, in a postonset model of sepsis. Design: Nonrandomized controlled study. Study Subjects: Young Yorkshireswine. Interventions: Three groups were studied. Controls (n=8) received saline solution only. Untreated animals with sepsis (n=8) receiveda 1-hour intravenous infusion of live Pseudomonas aeruginosa. Animalstreated with EL-246 (n=6) received the same bacterial infusion and a 2-mg/kg bolus of EL-246 at 30 minutes. Outcome Measures: Systemic and pulmonary hemodynamics, arterial blood gas determination, bronchoalveolar lavage protein and neutrophil content, neutrophil integrin and selectin expression, neutrophil oxidant burst, and organ myeloperoxidase content. Results: Treatment with EL-246 significantly reduced lung injury, as indicated by improved bronchoalveolar lavage protein and neutrophil content, resulting in a significant improvement in arterial oxygenation. This reduction in lung injury was produced by a reduction in lung myeloperoxidase content. Treatment with EL-246 failed to prevent the development of pulmonary hypertension and systemic hypotension. Neutrophils from animals with sepsis exhibited significant activation and upregulation of CD18, shedding of L-selectin, and production of increased levels of oxidants compared with controls. Conclusion: Treatmentof animals with EL-246 soon the onset of sepsis produced significant protection against acute lung injury but failed to attenuate hemodynamic derangements associated with sepsis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 12:07:51