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Titolo:
THE INTERLEUKIN 1-BETA-CONVERTING ENZYME-INHIBITOR CRMA PREVENTS APO1FAS-INDUCED BUT NOT GLUCOCORTICOID-INDUCED POLY(ADP-RIBOSE) POLYMERASE CLEAVAGE AND APOPTOSIS IN LYMPHOBLASTIC-LEUKEMIA CELLS/
Autore:
GELEY S; HARTMANN BL; KAPELARI K; EGLE A; VILLUNGER A; HEIDACHER D; GREIL R; AUER B; KOFLER R;
Indirizzi:
INNSBRUCK UNIV,INST GEN & EXPT PATHOL,DIV MOL PATHOPHYSIOL,FRITZ PREGL STR 3 A-6020 INNSBRUCK AUSTRIA INNSBRUCK UNIV,INST GEN & EXPT PATHOL,DIV MOL PATHOPHYSIOL A-6020 INNSBRUCK AUSTRIA INNSBRUCK UNIV,UNIV HOSP INTERNAL MED,DIV HEMATOL A-6020 INNSBRUCK AUSTRIA INNSBRUCK UNIV,INST BIOCHEM A-6020 INNSBRUCK AUSTRIA
Titolo Testata:
FEBS letters
fascicolo: 1, volume: 402, anno: 1997,
pagine: 36 - 40
SICI:
0014-5793(1997)402:1<36:TI1ECP>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEATH GENE CED-3; CONVERTING-ENZYME; IL-1-BETA-CONVERTING ENZYME; INTERLEUKIN-1-BETA-CONVERTING ENZYME; CYSTEINE PROTEASES; MEDIATED APOPTOSIS; MAMMALIAN HOMOLOG; MICE DEFICIENT; DNA CLEAVAGE; INDUCTION;
Keywords:
APOPTOSIS; GLUCOCORTICOID; PROTEASE; ICE; APO1/FAS; HUMAN; LEUKEMIA; T-CELL; POLY(ADP-RIBOSE) POLYMERASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
S. Geley et al., "THE INTERLEUKIN 1-BETA-CONVERTING ENZYME-INHIBITOR CRMA PREVENTS APO1FAS-INDUCED BUT NOT GLUCOCORTICOID-INDUCED POLY(ADP-RIBOSE) POLYMERASE CLEAVAGE AND APOPTOSIS IN LYMPHOBLASTIC-LEUKEMIA CELLS/", FEBS letters, 402(1), 1997, pp. 36-40

Abstract

Glucocorticoids (GC) induce programmed cell death (apoptosis) in immature lymphocytes and are an essential component in the therapy of acute lymphatic leukemia. The mechanism underlying GC-induced apoptosis particularly in leukemia cells is, however, not well understood, Most forms of apoptosis seem to employ a common final effector pathway characterized by specific proteolytic events mediated by interleukin 1 beta-converting enzyme (ICE) and/or other ICE-like cysteine proteases, These events may result in the morphologic changes characteristic of apoptosis, To determine whether a similar proteolytic pathway is activated during GC-induced leukemia cell apoptosis, we investigated poly(ADP-ribose) polymerase (PARP), a typical target of ICE-like proteases, during GC-induced apoptosis of the human acute T-cell leukemic cell line CEM-C7H2, Our studies showed proteolytic PARP cleavage suggestive of activation of ICE-like proteases that preceeded morphologic signs of apoptosis, We further established stably transfected CEM-C7H2 sublines expressing the cowpox virus protein CrmA that inhibits some, but not all,ICE-like proteases, GC-induced PARP cleavage and apoptosis mere neither inhibited nor delayed in crmA-expressing cell lines, In contrast, crmA expression rendered the same lines resistant to Apo1/Fas-induced PARP cleavage and apoptosis, Thus, different proteases might be activated during the effector phases of GC- and Apo1/Fas-induced apoptosis inhuman leukemia cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/05/20 alle ore 12:30:39