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Titolo:
MASSIVE CHRONIC INTERVILLOSITIS ASSOCIATED WITH RECURRENT ABORTIONS
Autore:
DOSS BJ; GREENE MF; HILL J; HEFFNER LJ; BIEBER FR; GENEST DR;
Indirizzi:
BRIGHAM & WOMENS HOSP,DEPT PATHOL,DIV WOMENS & PERINATAL PATHOL,75 FRANCIS ST BOSTON MA 02115 BRIGHAM & WOMENS HOSP,DEPT PATHOL,DIV WOMENS & PERINATAL PATHOL BOSTON MA 02115 BRIGHAM & WOMENS HOSP,DEPT OBSTET & GYNECOL BOSTON MA 02115 HARVARD UNIV,SCH MED BOSTON MA 00000 HARVARD UNIV,CTR RECURRENT MISCARRIAGE BOSTON MA 02115 MASSACHUSETTS GEN HOSP,DEPT OBSTET & GYNECOL BOSTON MA 02114 UNIV CHICAGO,DEPT PATHOL CHICAGO IL 60637
Titolo Testata:
Human pathology
fascicolo: 11, volume: 26, anno: 1995,
pagine: 1245 - 1251
SICI:
0046-8177(1995)26:11<1245:MCIAWR>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
MATERNAL FLOOR INFARCTION; SERUM ALPHA-FETOPROTEIN; UNKNOWN ETIOLOGY; PREGNANCY LOSS; VILLITIS; PLACENTA; WOMEN; CELLS; INFECTION; PRODUCTS;
Keywords:
RECURRENT ABORTION; SPONTANEOUS ABORTION; INTERVILLOSITIS; CHRONIC VILLITIS; ALPHA-FETOPROTEIN; TH1-TYPE CYTOKINES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
B.J. Doss et al., "MASSIVE CHRONIC INTERVILLOSITIS ASSOCIATED WITH RECURRENT ABORTIONS", Human pathology, 26(11), 1995, pp. 1245-1251

Abstract

Massive chronic intervillositis (MCI) is an unusual placental lesion associated with poor fetal growth and adverse pregnancy outcome; it has not previously been associated with spontaneous abortion or recurrent pregnancy loss. This article reports a patient who had 10 spontaneous abortions with repetitious massive chronic intervillositis documented in four of five gestations spanning all three trimesters. Characteristic placental histology included massive infiltration of the maternalintervillous space by chronic inflammatory cells and fibrin, without associated chronic villitis; the cellular infiltrate was composed predominantly of LCA and CD68 immunoreactive cells with scattered CD45RO positivity, consistent with a monocyte/macrophage population with occasional T lymphocytes. Elevated maternal serum alphafetoprotein was documented in two pregnancies, These findings support the concept that this unusual placental lesion may have an immunologic basis, and suggest that MCI may be a histopathologically recognizable cause of recurrent spontaneous abortion. Copyright (C) 1995 by W.B. Saunders Company

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 10:01:04