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Titolo:
ACETYLCHOLINE-RELEASE FROM DISSOCIATED STRIATAL CELLS
Autore:
LOGIN IS; BORLAND K; HARRISON MB; RAGOZZINO ME; GOLD PE;
Indirizzi:
UNIV VIRGINIA,HLTH SCI CTR,DEPT NEUROL,BOX 394 CHARLOTTESVILLE VA 22908 UNIV VIRGINIA,DEPT PSYCHOL CHARLOTTESVILLE VA 22908
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 697, anno: 1995,
pagine: 271 - 275
SICI:
0006-8993(1995)697:1-2<271:AFDSC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR-MEDIATED INHIBITION; DOPAMINERGIC REGULATION; RAT; ACTIVATION; NEURONS; CHANNELS; NUCLEUS; CORTEX;
Keywords:
ACETYLCHOLINE; CALCIUM; DISSOCIATED CELL; FRACTIONAL EFFLUX; GLUTAMATE; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; STRIATUM;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
I.S. Login et al., "ACETYLCHOLINE-RELEASE FROM DISSOCIATED STRIATAL CELLS", Brain research, 697(1-2), 1995, pp. 271-275

Abstract

To study the regulation of striatal acetylcholine (ACH) release, adult male rat striata were dissociated and incubated with 3H-choline to synthesize 3H-ACH. Fractional 3H-ACH efflux per min during continuous perifusion was: (1) tightly regulated; (2) dependent on calcium influx;(3) stimulated by 10 mM K+ and 1 mM glutamate; and (4) comparable to ACH release detected by HPLC. Thus, acutely dissociated striata exhibit calcium-sensitive, voltage-dependent secretion of 3H-ACH and direct receptor-mediated stimulation of release through the glutamate receptor family. This new approach toward cholinergic secretory physiology will help clarify complex striatal circuitry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 20:17:12