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Titolo:
7-NITRO-INDAZOLE, A SELECTIVE INHIBITOR OF NEURONAL NITRIC-OXIDE SYNTHASE, REDUCES FORMALIN EVOKED C-FOS EXPRESSION IN DORSAL HORN NEURONS OF THE RAT SPINAL-CORD
Autore:
CHAPMAN V; BURITOVA J; HONORE P; BESSON JM;
Indirizzi:
INSERM,U161,2 RUE ALESIA F-75014 PARIS FRANCE EPHE F-75014 PARIS FRANCE
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 697, anno: 1995,
pagine: 258 - 261
SICI:
0006-8993(1995)697:1-2<258:7ASION>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXHIBITS ANTINOCICEPTIVE ACTIVITY; ARGININE METHYL-ESTER; NOXIOUS-STIMULATION; 7-NITRO INDAZOLE; MOUSE;
Keywords:
NITRIC OXIDE; NOCICEPTION; SPINAL CORD;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
V. Chapman et al., "7-NITRO-INDAZOLE, A SELECTIVE INHIBITOR OF NEURONAL NITRIC-OXIDE SYNTHASE, REDUCES FORMALIN EVOKED C-FOS EXPRESSION IN DORSAL HORN NEURONS OF THE RAT SPINAL-CORD", Brain research, 697(1-2), 1995, pp. 258-261

Abstract

The effect of intravenous 7-nitro-indazole (7NI), a selective inhibitor of neuronal nitric oxide synthase, on intraplantar formalin evoked spinal expression of c-Fos was studied. The spinal expression of c-Fosin the superficial laminae of the dorsal horn was not significantly altered by 7NI. In contrast formalin evoked c-Fos expression in the deep laminae was reduced by 15 mg/kg of 7NI (42 +/- 8% reduction of control P < 0.05). Formalin evoked inflammation was not influenced by 7NI. Our results implicate a functional relationship between c-Fos expression and nitric oxide, at the spinal level, under inflammatory conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/08/20 alle ore 14:35:02