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Titolo:
LOSS OF TRANSPORTER IN ANTIGEN-PROCESSING-1 TRANSPORT PROTEIN AND MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I MOLECULES IN METASTATIC VERSUS PRIMARY BREAST-CANCER
Autore:
KAKLAMANIS L; LEEK R; KOUKOURAKIS M; GATTER KC; HARRIS AL;
Indirizzi:
CHURCHILL HOSP,IMPERIAL CANC RES FUND,CLIN ONCOL UNIT OXFORD OX3 7LJ ENGLAND CHURCHILL HOSP,IMPERIAL CANC RES FUND,CLIN ONCOL UNIT OXFORD OX3 7LJ ENGLAND JOHN RADCLIFFE HOSP,NUFFIELD DEPT PATHOL OXFORD OX3 9DU ENGLAND UNIV OXFORD,JOHN RADCLIFFE HOSP,DEPT CELLULAR SCI OXFORD OX3 9DU ENGLAND
Titolo Testata:
Cancer research
fascicolo: 22, volume: 55, anno: 1995,
pagine: 5191 - 5194
SICI:
0008-5472(1995)55:22<5191:LOTIAT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
HLA CLASS-I; MHC CLASS-I; CELL-LINES; GAMMA-INTERFERON; EXPRESSION; MODULATION; REGION; GENE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
L. Kaklamanis et al., "LOSS OF TRANSPORTER IN ANTIGEN-PROCESSING-1 TRANSPORT PROTEIN AND MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I MOLECULES IN METASTATIC VERSUS PRIMARY BREAST-CANCER", Cancer research, 55(22), 1995, pp. 5191-5194

Abstract

We studied by inmunohistochemistry the HLA-allelic, beta(2)-microglobulin, and TAP-1 expression in primary breast carcinomas and related lymph node metastases, Thirty-three of the primary tumors and 44% of thelymph node metastases had a complete HLA class I loss. The higher incidence of antigenic loss in metastatic tumors suggests that recognition of HLA class I antigens by the host immunity could have an importantrole in the metastatic evolution of breast cancer, We observed a simultaneous defective expression of all three components involved in HLA class I expression, Since the controlling genes of heavy chain and TAP-1 are located in different chromosome than beta(2)-microglobulin, it could be that a common factor exists regulating MA class I antigenic expression, Five of 25 (20%) primary and metastatic tumors from HLA-A2-positive individuals also had a selective loss, The high incidence of HLA class I loss in breast cancer patients shows that adjuvant immunotherapy to induce HLA class I expression could be of value in a subgroup of patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 15:04:11