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Titolo:
HIV IS TRAPPED AND MASKED IN THE CYTOPLASM OF LYMPH-NODE FOLLICULAR DENDRITIC CELLS
Autore:
TACCHETTI C; FAVRE A; MORESCO L; MESZAROS P; LUZZI P; TRUINI M; RIZZO F; GROSSI CE; CICCONE E;
Indirizzi:
FAC MED & CHIRURG,IST ANAT UMANA,VIA TONI 14 I-16132 GENOA ITALY UNIV GENOA,DEPT HUMAN ANAT GENOA ITALY UNIV GENOA,DEPT CLIN & EXPT ONCOL GENOA ITALY SAN MARTINO HOSP,NATL INST CANC RES GENOA ITALY SAN MARTINO HOSP,DIV PATHOL GENOA ITALY SAN MARTINO HOSP,DIV INFECT DIS GENOA ITALY
Titolo Testata:
The American journal of pathology
fascicolo: 2, volume: 150, anno: 1997,
pagine: 533 - 542
SICI:
0002-9440(1997)150:2<533:HITAMI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
GERMINAL-CENTER; INFECTION; AIDS; TISSUE; PATHOGENESIS; LYMPHOCYTES; MACROPHAGES; MORPHOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
C. Tacchetti et al., "HIV IS TRAPPED AND MASKED IN THE CYTOPLASM OF LYMPH-NODE FOLLICULAR DENDRITIC CELLS", The American journal of pathology, 150(2), 1997, pp. 533-542

Abstract

To gain further insight into the pathogenesis of human immunodeficiency virus (HIV) infection, lymph nodes from seven asymptomatic HIV+ subjects were analyzed during the latent phase of disease. Both ultrastructural and immunohistochemical analyses revealed that, in all of the cases, plasma cells producing IgM/lambda were present in germinal centers. Secreted immunoglobulins formed extracellular deposits mimicking the follicular dendritic cell network. Immunoglobulin produced by germinal center plasma cells are specific for HIV because they bind the HIVenv protein gp120. Plasma cells producing antibodies with the same specificity were also abundant in the extrafollicular regions of lymph nones. During the latent phase of infection, the virus largely accumulates within the germinal centers. Therefore, extracellular immunoglobulin may form immune complexes, as shown by the presence of HIV-specificantibodies, HIV particles, and complement components C3c, C3d, and C1q in the interdendritic spaces. When the ultrastructural localization of HIV in germinal centers was analyzed abundant virus particles were found in the interdendritic spaces. In addition to this extracellular localization of HIV, receptor-mediated endocytosis of viral particles by follicular dendritic cells was observed. Complete HIV particles were found within the endosomal compartment of the follicular dendritic cells and as complete viral particles, free in the cytoplasm, indicating that the virus may escape front the endocytic compartment. As the virus is abundant in the cytoplasm, this event leads to formation of a hidden reservoir within follicular dendritic cells. In this location, HIV escapes recognition by cytotoxic T lymphocytes. In contrast, virus budding indicating a productive infection of follicular dendritic cells that would render them susceptible to T-cell-mediated lysis has beenseldom observed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 19:48:52