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Titolo:
REACTIVE ANTIBODIES IN SERA FROM PUBERTAL AND ADULT GINGIVITIS PATIENTS AGAINST VARIOUS PORPHYROMONAS-GINGIVALIS ANTIGENS
Autore:
NAKAGAWA T; NAKAGAWA S; ISHIHARA K; YAMADA S; MACHIDA Y; OKUDA K;
Indirizzi:
TOKYO DENT COLL,DEPT PERIODONT,MIHAMA KU,1-2-2 MASAGO CHIBA 261 JAPAN TOKYO DENT COLL,DEPT PEDIAT DENT,MIHAMA KU CHIBA 261 JAPAN TOKYO DENT COLL,DEPT MICROBIOL,MIHAMA KU CHIBA 261 JAPAN
Titolo Testata:
Journal of Periodontal Research
fascicolo: 6, volume: 30, anno: 1995,
pagine: 396 - 403
SICI:
0022-3484(1995)30:6<396:RAISFP>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANAEROBE BACTEROIDES-GINGIVALIS; PERIODONTAL-DISEASE; ACTINOBACILLUS-ACTINOMYCETEMCOMITANS; ASACCHAROLYTICUS; PURIFICATION; BACTERIA; FIMBRIAE; INTERMEDIUS; ATTACHMENT; PATTERNS;
Keywords:
P-GINGIVALIS; IGG RESPONSE; GINGIVITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
T. Nakagawa et al., "REACTIVE ANTIBODIES IN SERA FROM PUBERTAL AND ADULT GINGIVITIS PATIENTS AGAINST VARIOUS PORPHYROMONAS-GINGIVALIS ANTIGENS", Journal of Periodontal Research, 30(6), 1995, pp. 396-403

Abstract

This study was undertaken to determine the immunodominant antigens from Porphyromonas gingivalis which reacted with sera from patients of pubertal and adult gingivitis. The patients with cultivable P. gingivalis and the patients without cultivable P. gingivalis were compared by immunoblots. Fifty subjects participated in this study: 20 with gingivitis, 20 periodontally healthy, and 10 with adult periodontitis. The groups with gingivitis and healthy periodontium each contained 10 pubescent subjects and 10 adult subjects. P. gingivalis was isolated from 9of 20 patients with gingivitis and from all of 10 with periodontitis by culture study. Approximate molecular weight 43 KDa fimbriae antigen, 57, 53, 46, 28 KDa antigens from outer membrane, and 57, 44, 40, 18.5 KDa antigens from sonicated extracts of P. gingivalis reacted significantly more frequently with sera from the P. gingivalis culture-positive gingivitis patients than with sera from the culture-negative patients by Fisher's exact test. A molecular weight 75, 31 KDa antigen fromouter membrane and a 46 KDa antigen from sonicated extract were immunodominant in sera from adult patients with periodontitis. These findings indicate that the specific antigens which reacted with sera from P.gingivalis culture-positive patients are markers of infection with P.gingivalis. Additionally, reactivity to antigens were slightly different between sera from patients with gingivitis and those from patientswith periodontitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 15:41:39