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Titolo:
PLASMA AND URINE MEASUREMENTS FOR MONITORING OF TREATMENT IN THE PRIMARY HYPEROXALURIC PATIENT
Autore:
KASIDAS GP;
Indirizzi:
UNIV COLL LONDON,HOSP TRUST,WINDEYER BLDG,46 CLEVELAND ST LONDON W1P 6DB ENGLAND
Titolo Testata:
Nephrology, dialysis, transplantation
, volume: 10, anno: 1995, supplemento:, 8
pagine: 8 - 10
SICI:
0931-0509(1995)10:<8:PAUMFM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ION CHROMATOGRAPHIC DETERMINATION; HEALTHY-SUBJECTS; RENAL-FAILURE; OXALATE; ASCORBATE; REMOVAL; TYPE-1; ACID; KIT;
Keywords:
PRIMARY HYPEROXALURIA; OXALATE; ANALYSIS; TREATMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
G.P. Kasidas, "PLASMA AND URINE MEASUREMENTS FOR MONITORING OF TREATMENT IN THE PRIMARY HYPEROXALURIC PATIENT", Nephrology, dialysis, transplantation, 10, 1995, pp. 8-10

Abstract

Reliable methods for the assaying of oxalate in biological fluids arenow available. However, preanalytical sample collection and storage conditions are critical to produce meaningful results for the diagnosisand assessment of treatment modalities in primary hyperoxaluria. Spontaneous in vitro generation of oxalate from ascorbate is possible, especially in plasma measurements, where the ascorbate to oxalate ratio is considerably greater than that of urine. The pH of blood also favours the conversion of ascorbate to oxalate. Losses, as well as generation of oxalate can occur in urine when collection procedures are inadequate. Analysis of properly collected samples is of greater assistance in monitoring the efficacy of treatment modalities in oxaluric patients. Routine and reliable assays are still needed for other closely related organic acid anions such as glycolate and L-glycerate. Measurement of these anions can facilitate the diagnosis and assist in monitoring of treatment in the different forms of primary hyperoxaluria.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 09:40:06