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Titolo:
THE MECHANISMS BY WHICH HYPERBARIC-OXYGEN AND CARBOGEN IMPROVE TUMOR OXYGENATION
Autore:
BRIZEL DM; LIN S; JOHNSON JL; BROOKS J; DEWHIRST MW; PIANTADOSI CA;
Indirizzi:
DUKE UNIV,MED CTR,DEPT RADIAT ONCOL,BOX 3085 DURHAM NC 27710 DUKE UNIV,MED CTR,DEPT MED DURHAM NC 27710 DUKE UNIV,MED CTR,DEPT FAMILY MED,DIV BIOMETRY DURHAM NC 00000
Titolo Testata:
British Journal of Cancer
fascicolo: 5, volume: 72, anno: 1995,
pagine: 1120 - 1124
SICI:
0007-0920(1995)72:5<1120:TMBWHA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIATION-THERAPY; NORMOBARIC OXYGEN; PHASE-I/II; CARCINOMA; ADJUVANT; FLUOSOL; HEAD; NECK;
Keywords:
OXYGEN; HYPERBARIC OXYGEN; CARBOGEN; TUMOR OXYGENATION; CARBON DIOXIDE; POLAROGRAPHIC MICROELECTRODE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
D.M. Brizel et al., "THE MECHANISMS BY WHICH HYPERBARIC-OXYGEN AND CARBOGEN IMPROVE TUMOR OXYGENATION", British Journal of Cancer, 72(5), 1995, pp. 1120-1124

Abstract

Hyperbaric oxygen (HBO) has been proposed to reduce tumour hypoxia byincreasing the amount of dissolved oxygen in the plasma. That this actually occurs has not been verified experimentally. This study was performed to explore changes in tumour oxygenation induced by treatment with normobaric and hyperbaric oxygen and carbogen. R3230Ac mammary adenocarcinomas were implanted into Fischer 344 rats. Arterial blood gases, blood pressure and heart rate were monitored. Tumour oxygenation was measured polarographically in five sets of animals. They received either normobaric 100% oxygen, hyperbaric (3 atmospheres; atm) 100% oxygen, normobaric carbogen or hyperbaric (3 atm) carbogen (HBC) +/- bretylium. HBO reduced the mean level of low pO(2) values (<5 mmHg) from 0.49 to 0.07 (P = 0.0003) and increased the average median pO(2) from 8 mmHg to 55 mmHg (P = 0.001). HBC reduced the level of low pO(2) valuesfrom 0.82 to 0.51 (P = 0.002) and increased median pO(2) from 2 mmHg to 6 mmHg (P = 0.05). Normobaric oxygen and carbogen did not change tumour oxygenation significantly. Sympathetic blockade with bretylium before HBC exposure improved oxygenation significantly more than HBC alone (low pO(2) 0.55-0.17, median pO(2) 4-17 mmHg). HBO and hyperbaric carbogen improved tumour oxygenation in this model, while normobaric oxygen or carbogen had no effect. Sympathetic-mediated vasoconstriction during hyperbaric carbogen caused it to be less effective than HBO. This mechanism also appeared to operate during normobaric carbogen breathing.

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Documento generato il 07/04/20 alle ore 04:12:04