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Titolo:
CALSEQUESTRIN IS ESSENTIAL FOR THE CA2-ALPHA IN SKELETAL-MUSCLE SARCOPLASMIC-RETICULUM( RELEASE INDUCED BY MYOTOXIN)
Autore:
OHKURA M; IDE T; FURUKAWA K; KAWASAKI T; KASAI M; OHIZUMI Y;
Indirizzi:
TOHOKU UNIV,INST PHARMACEUT,DEPT PHARMACEUT MOLEC BIOL SENDAI MIYAGI 980 JAPAN TOHOKU UNIV,INST PHARMACEUT,DEPT PHARMACEUT MOLEC BIOL SENDAI MIYAGI 980 JAPAN OSAKA UNIV,FAC ENGN SCI,DEPT BIOPHYS ENGN TOYONAKA OSAKA 560 JAPAN
Titolo Testata:
Canadian journal of physiology and pharmacology
fascicolo: 8, volume: 73, anno: 1995,
pagine: 1181 - 1185
SICI:
0008-4212(1995)73:8<1181:CIEFTC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALCIUM RELEASE;
Keywords:
CALSEQUESTRIN; MYOTOXIN ALPHA; CA2+ RELEASE; CA2+ RELEASE CHANNELS; SARCOPLASMIC RETICULUM;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
M. Ohkura et al., "CALSEQUESTRIN IS ESSENTIAL FOR THE CA2-ALPHA IN SKELETAL-MUSCLE SARCOPLASMIC-RETICULUM( RELEASE INDUCED BY MYOTOXIN)", Canadian journal of physiology and pharmacology, 73(8), 1995, pp. 1181-1185

Abstract

Myotoxin alpha (MYTX), a polypeptide toxin purified from the venom ofprairie rattlesnakes (Crotalus viridis viridis), induced Ca2+ releasefrom the heavy fraction of skeletal sarcoplasmic reticulum (HSR), using a Ca2+ electrode. The effect of MYTX was nearly abolished by pretreatment with ryanodine, an alkaloid-based Ca2+ channel blocker. In the stopped-flow experiments, MYTX increased the choline(+) permeability of HSR in the presence of calsequestrin (CS). Single channel recording experiments showed that in the presence of CS, the channel currents were markedly enhanced by MYTX applied to the cis side, but not to the trans side. However, in the absence of CS, MYTX failed to cause the excitatory effect in both the experiments. These results suggest that CS is essential for MYTX-induced Ca2+ release through the Ca2+ release channels in skeletal HSR.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 06:32:30