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Titolo:
DETECTION OF SQUAMOUS NEOPLASIA BY FLUORESCENCE IMAGING COMPARING PORFIMER SODIUM FLUORESCENCE TO TISSUE AUTOFLUORESCENCE IN THE HAMSTER-CHEEK POUCH MODEL
Autore:
PATHAK I; DAVIS NL; HSIANG YN; QUENVILLE NF; PALCIC B;
Indirizzi:
UNIV BRITISH COLUMBIA,DEPT SURG,910 W 10TH AVE,3RD FLOOR VANCOUVER BCV5Z 4E3 CANADA UNIV BRITISH COLUMBIA,DEPT SURG VANCOUVER BC V5Z 4E3 CANADA UNIV BRITISH COLUMBIA,DEPT PATHOL VANCOUVER BC V5Z 4E3 CANADA VANCOUVER HOSP & HLTH SCI CTR VANCOUVER BC CANADA BRITISH COLUMBIA CANC AGCY,DIV MED PHYS,CANC IMAGING SECT VANCOUVER BC V5Z 4E6 CANADA
Titolo Testata:
The American journal of surgery
fascicolo: 5, volume: 170, anno: 1995,
pagine: 423 - 426
SICI:
0002-9610(1995)170:5<423:DOSNBF>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARCINOMA INSITU; CANCER; LUNG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
I. Pathak et al., "DETECTION OF SQUAMOUS NEOPLASIA BY FLUORESCENCE IMAGING COMPARING PORFIMER SODIUM FLUORESCENCE TO TISSUE AUTOFLUORESCENCE IN THE HAMSTER-CHEEK POUCH MODEL", The American journal of surgery, 170(5), 1995, pp. 423-426

Abstract

BACKGROUND: Early neoplastic changes in the oral cavity may be difficult to detect. Fluorescence imaging using porphyrin-derived drugs has been used to enhance detection of neoplasia. Autofluorescence has alsobeen used for this purpose. This paper compares autofluorescence to porfimer sodium-induced fluorescence in the detection of neoplasia in the hamster cheek-pouch model. MATERIALS AND METHODS: Neoplasia was induced in the hamster cheek pouch by the application of 9,10-dimethyl-1,2-benzanthracene. Animals were imaged either with injection of drug (porfimer sodium) or without drug (autofluorescence). Imaging was carried out using a laser-induced fluorescence detection system. Biopies were performed on imaged sections and histologic grades were assigned. RESULTs: Porfimer sodium fluorescence provided 100% sensitivity and specificity in detection of neoplasia. The sensitivity and specificity with autofluorescence was 76% and 83%, respectively. CONCLUSIONS: Autofluorescence provides an accurate means of detecting early neoplastic changes in the hamster cheek-pouch model; however, porfimer sodium imaging does improve detection rates.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 05:00:19