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Titolo:
PERSISTENCE OF LONG-LASTING SEROTONIN DEPLETION BY P-CHLOROAMPHETAMINE IN RAT-BRAIN AFTER 6-HYDROXYDOPAMINE LESIONING OF DOPAMINE NEURONS
Autore:
PERRY KW; KOSTRZEWA RM; FULLER RW;
Indirizzi:
ELI LILLY & CO,LILLY RES LABS INDIANAPOLIS IN 46185 ELI LILLY & CO,LILLY RES LABS INDIANAPOLIS IN 46185 E TENNESSEE STATE UNIV,SCH MED JOHNSON CITY TN 37614
Titolo Testata:
Biochemical pharmacology
fascicolo: 8, volume: 50, anno: 1995,
pagine: 1305 - 1307
SICI:
0006-2952(1995)50:8<1305:POLSDB>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYDROXYLASE-ACTIVITY; 3,4-METHYLENEDIOXYMETHAMPHETAMINE; 5-HYDROXYTRYPTAMINE; METHAMPHETAMINE; NEUROTOXICITY; DEFICITS;
Keywords:
P-CHLOROAMPHETAMINE; SEROTONIN; DOPAMINE; 6-HYDROXYDOPAMINE; STRIATUM; HIPPOCAMPUS;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
K.W. Perry et al., "PERSISTENCE OF LONG-LASTING SEROTONIN DEPLETION BY P-CHLOROAMPHETAMINE IN RAT-BRAIN AFTER 6-HYDROXYDOPAMINE LESIONING OF DOPAMINE NEURONS", Biochemical pharmacology, 50(8), 1995, pp. 1305-1307

Abstract

In rats that had been treated neonatally with 6-hydroxydopamine (6OHDA) to deplete striatal dopamine more than 95%, a single injection of p-chloroamphetamine (pCA) (5 or 10 mg/kg, i.p.) resulted in depletion of striatal and hippocampal serotonin at 1 week to a similar extent as in control rats. These findings suggest that striatal dopamine is not essential to the long-lasting depletion of brain serotonin by pCA in rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 22:09:56