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Titolo:
DISTURBED MHC REGULATION IN THE IFN-GAMMA KNOCKOUT MOUSE - EVIDENCE FOR 3 STATES OF MHC EXPRESSION WITH DISTINCT ROLES FOR IFN-GAMMA
Autore:
GOES N; SIMS T; URMSON J; VINCENT D; RAMASSAR V; HALLORAN PF;
Indirizzi:
UNIV ALBERTA,DEPT MED,DIV NEPHROL & IMMUNOL,205,8249-114 ST EDMONTON AB T6G 2R8 CANADA UNIV ALBERTA,DEPT MED,DIV NEPHROL & IMMUNOL EDMONTON AB T6G 2R8 CANADA
Titolo Testata:
The Journal of immunology
fascicolo: 10, volume: 155, anno: 1995,
pagine: 4559 - 4566
SICI:
0022-1767(1995)155:10<4559:DMRITI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASS-II ANTIGEN; INTERFERON-GAMMA; GENE-EXPRESSION; T-CELLS; IMMUNE-RESPONSE; MESSENGER-RNA; MICE; RECEPTOR; INVIVO; LIPOPOLYSACCHARIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
N. Goes et al., "DISTURBED MHC REGULATION IN THE IFN-GAMMA KNOCKOUT MOUSE - EVIDENCE FOR 3 STATES OF MHC EXPRESSION WITH DISTINCT ROLES FOR IFN-GAMMA", The Journal of immunology, 155(10), 1995, pp. 4559-4566

Abstract

We compared the expression of MHC class I and II products in tissues of IFN-gamma knockout (GKO) vs normal (wild-type) BALB/c mice. We studied expression in the basal state, after local tissue injury, after stimuli that induce systemic MHC expression (allogeneic cells, oxazoloneskin painting, or LPS), and after rIFN-gamma. Basal class II expression in interstitial cells was not reduced in GKO mice. However, GKO mice had less basal class I expression in kidney, liver, heart, and arterial endothelium than wild-type mice. Local renal ischemic injury increased class I and II expression in kidney tubules of both GKO and wild-type mice, but induction in GKO was less than in wild-type. Potent inflammatory stimuli increased systemic MHC class I and II markedly in kidney, liver, and heart of wild-type mice, but induced no increase in GKO mice. rIFN-gamma induced class I and II equally in GKO and wild-type mice. Thus, three states of MHC expression can be defined that differ in their dependencies on IFN-gamma: basal, locally induced, and systemically induced. Basal class II expression in interstitial cells is IFN-gamma independent, but basal class I expression, particularly in arterial endothelium, is partially dependent an IFN-gamma. The local increase in MHC class I and II in parenchymal cells in response to injuryreflects both IFN-gamma and a non-IFN-gamma factor. Systemic MHC class I and II induction is almost exclusively due to IFN-gamma.

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Documento generato il 29/09/20 alle ore 20:39:50