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Titolo:
TSH RECEPTOR SEQUENCES RECOGNIZED BY CD4(-CELLS IN GRAVES-DISEASE PATIENTS AND HEALTHY CONTROLS() T)
Autore:
KELLERMANN SA; MCCORMICK DJ; FREEMAN SL; MORRIS JC; CONTIFINE BM;
Indirizzi:
UNIV MINNESOTA,COLL BIOL SCI,DEPT BIOCHEM,1479 GORTNER AVE ST PAUL MN55108 UNIV MINNESOTA,COLL BIOL SCI,DEPT BIOCHEM ST PAUL MN 55108 MAYO CLIN & MAYO GRAD SCH MED,DEPT BIOCHEM & MOLEC BIOL ROCHESTER MN 55905 ST PAUL RAMSEY MED CTR,ENDOCRINOL SECT ST PAUL MN 55101 UNIV MINNESOTA,SCH MED,ENDOCRINOL SECT MINNEAPOLIS MN 55455 MAYO CLIN & MAYO GRAD SCH MED,DEPT MED,DIV ENDOCRINOL & METAB ROCHESTER MN 55905 UNIV MINNESOTA,SCH MED,DEPT PHARMACOL MINNEAPOLIS MN 55455
Titolo Testata:
Journal of autoimmunity
fascicolo: 5, volume: 8, anno: 1995,
pagine: 685 - 698
SICI:
0896-8411(1995)8:5<685:TRSRBC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYELIN BASIC-PROTEIN; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; HUMAN ACETYLCHOLINE-RECEPTOR; MYASTHENIA-GRAVIS; TOLERANCE INDUCTION; MULTIPLE-SCLEROSIS; ALPHA-SUBUNIT; HETEROGENEITY; IMMUNIZATION; AUTOANTIGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
S.A. Kellermann et al., "TSH RECEPTOR SEQUENCES RECOGNIZED BY CD4(-CELLS IN GRAVES-DISEASE PATIENTS AND HEALTHY CONTROLS() T)", Journal of autoimmunity, 8(5), 1995, pp. 685-698

Abstract

Twenty-nine overlapping synthetic peptides, twenty residues long, representing the entire extracellular sequence of the human thyroid stimulating hormone receptor (hTSHr), were used to test the epitope repertoire of CD4(+) T lymphocytes from patients with Graves' disease and from healthy subjects. The peptides were used to propagate and test shortterm CD4(+) T cell lines specific for hTSHr epitopes, and to directlytest CD8(+) depleted, CD4(+) enriched peripheral blood lymphocytes. Analysis of the response of short-term CD4(+) T cell lines and CD8(+) depleted peripheral blood lymphocytes to the individual peptides revealed that 14 of the 15 patients and nine of the ten controls responded to at least one hTSHr peptide. There was no common response pattern, nor any region of the hTSHr sequence that was predominantly recognized. Several peptides were recognized by both patients and controls. These results support the notion that immunological tolerance to hTSHr is due to peripheral tolerance of potentially autoreactive CD4(+) T cells, not their clonal deletion. The presence of self-reactive, hTSHr-specific CD4(+) T cells in healthy individuals implies that these cells are not permanently anergized, since they can be activated in vitro. (C) 1995 Academic Press Limited

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:14:28