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Titolo:
PREFERENTIAL SENSITIVITY OF ACROCENTRIC CHROMOSOMES TO THE ANEUGENIC EFFECT OF COLCHICINE
Autore:
CARIA H; CHAVECA T; RUEFF J;
Indirizzi:
NEW UNIV LISBON,FAC MED SCI,DEPT GENET,RUA JUNQUEIRA 96 P-1300 LISBONPORTUGAL NEW UNIV LISBON,FAC MED SCI,DEPT GENET P-1300 LISBON PORTUGAL UNIV LISBON,FAC PHARM P-1699 LISBON PORTUGAL
Titolo Testata:
Teratogenesis, carcinogenesis, and mutagenesis
fascicolo: 5, volume: 16, anno: 1996,
pagine: 243 - 252
SICI:
0270-3211(1996)16:5<243:PSOACT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANEUPLOIDY-INDUCING AGENTS; HUMAN-LYMPHOCYTES; MICRONUCLEI; DNA;
Keywords:
DOWN SYNDROME; ACROCENTRIC CHROMOSOME; COLCHICINE; MICRONUCLEI; C-BANDING; CREST STAINING; N-BANDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
H. Caria et al., "PREFERENTIAL SENSITIVITY OF ACROCENTRIC CHROMOSOMES TO THE ANEUGENIC EFFECT OF COLCHICINE", Teratogenesis, carcinogenesis, and mutagenesis, 16(5), 1996, pp. 243-252

Abstract

In order to evaluate the predisposition to the aneuploidy-inducing agent colchicine (Col) on lymphocytes from trisomic 21 patients comparedwith their parents and with a control group of subjects without trisomic children, we performed the micronucleus (MN) assay associated withC-banding, CREST staining, and nucleolar organizing region (NOR)-banding. According to our results Col behaves as an aneugenic agent independently of the population studied for CREST and C-banding. The Col-induced MN exhibited a clear majority (>80%) of positive NOR-MN, meaning that they contain a NOR region transcriptionally active or inactive. The same data were observed in trisomic 21 individuals, their parents, and the control group, without significant differences between them. These results seem to suggest a preferential effect of the aneugen Col on acrocentric chromosomes in all of the three groups studied. (C) 1997 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 14:06:32