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Titolo:
AN ICE-LIKE PROTEASE IS A COMMON MEDIATOR OF APOPTOSIS INDUCED BY DIVERSE STIMULI IN HUMAN MONOCYTIC THP.1 CELLS
Autore:
ZHU HJ; FEARNHEAD HO; COHEN GM;
Indirizzi:
UNIV LEICESTER,MRC,TOXICOL UNIT,POB 138,LANCASTER RD LEICESTER LE1 9HN LEICS ENGLAND UNIV LEICESTER,MRC,TOXICOL UNIT LEICESTER LE1 9HN LEICS ENGLAND
Titolo Testata:
FEBS letters
fascicolo: 2, volume: 374, anno: 1995,
pagine: 303 - 308
SICI:
0014-5793(1995)374:2<303:AIPIAC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEATH GENE CED-3; INTERNUCLEOSOMAL FRAGMENTATION; THYMOCYTES; CLEAVAGE; DNA; CAMPTOTHECIN; MECHANISMS; INDUCTION; ENZYME; DRUGS;
Keywords:
APOPTOSIS; ICE-LIKE PROTEASES; THP.1 CELL; Z-VAL-ALA-ASP FLUOROMETHYLKETONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
H.J. Zhu et al., "AN ICE-LIKE PROTEASE IS A COMMON MEDIATOR OF APOPTOSIS INDUCED BY DIVERSE STIMULI IN HUMAN MONOCYTIC THP.1 CELLS", FEBS letters, 374(2), 1995, pp. 303-308

Abstract

Apoptosis was induced in THP.1 cells, a human monocytic tumour cell line, by diverse stimuli including cyclo-heximide, thapsigargin, etoposide and staurosporine. Induction of apoptosis by all these stimuli, except etoposide, was enhanced in the presence of the trypsin-like protease inhibitor, N alpha-tosyl-L-lysinyl chloromethyl ketone (TLCK), Induction of apoptosis, assessed by morphological, flow cytometric and biochemical criteria, including proteolysis of poly(ADP-ribose) polymerase and cleavage of DNA to large kilobasepair fragments, was completelyabrogated when cells were pretreated with an ICE-like protease inhibitor, Z-Val-Ala-Asp . fluoromethylketone. This suggested that an ICE homologue was a common mediator of apoptosis in THP.1 cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:25:03