Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
VIRAL PHENOTYPE AND GENOTYPE AS MARKERS IN CLINICAL-TRIALS
Autore:
KATZENSTEIN DA;
Indirizzi:
STANFORD UNIV,MED CTR,CTR AIDS RES,S156 STANFORD CA 94305
Titolo Testata:
Journal of acquired immune deficiency syndromes and human retrovirology
, volume: 10, anno: 1995, supplemento:, 2
pagine: 25 - 34
SICI:
1077-9450(1995)10:<25:VPAGAM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; BLOOD MONONUCLEAR-CELLS; HIV-1 REVERSE-TRANSCRIPTASE; SYNCYTIUM-INDUCING PHENOTYPE; TERM INFECTED INDIVIDUALS; AIDS-RELATED COMPLEX; T-CELL; ZIDOVUDINE RESISTANCE; BIOLOGICAL PHENOTYPE; DISEASE PROGRESSION;
Keywords:
AIDS; HIV INFECTION; SURROGATE MARKERS; VIRAL PHENOTYPE; CLINICAL TRIALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
89
Recensione:
Indirizzi per estratti:
Citazione:
D.A. Katzenstein, "VIRAL PHENOTYPE AND GENOTYPE AS MARKERS IN CLINICAL-TRIALS", Journal of acquired immune deficiency syndromes and human retrovirology, 10, 1995, pp. 25-34

Abstract

Treatment of AIDS and HIV infection is increasingly dependent on the use of surrogate markers to assess the efficacy of drug and biologic therapies in individual patients and in the clinical trials. Recent developments in laboratory techniques have resulted in new assays to measure circulating viral RNA in HIV-infected individuals, standardized methods to assess genotypic changes in virus associated with drug resistance and biologic assays for syncytia-inducing phenotype, a viral characteristic associated with rapid clinical progression. Studies from our laboratory have examined the relationship between surrogate markers of drug efficacy, CD4 cell changes, quantitative HIV plasma RNA and cell dilution cultures, genotypic changes associated with drug resistance and the syncytia-inducing phenotype. The results of these studies suggest that drug-resistance genotype and syncytia-inducing phenotype are independent factors that contribute to disease progression in patients receiving zidovudine. The design of studies of drugs and biologics for the treatment of HIV should include assessment of genotypic and phenotypic characteristics of HIV in addition to CD4 cell numbers and virus load.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 06:51:13