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Titolo:
REGULATION OF MELATONIN PRODUCTION AND INTRACELLULAR CALCIUM CONCENTRATIONS IN THE TROUT PINEAL ORGAN
Autore:
MEISSL H; KROEBER S; YANEZ J; KORF HW;
Indirizzi:
MAX PLANCK INST PHYSIOL & CLIN RES,WG KERCKHOFF INST,PK STR 1 D-61231BAD NAUHEIM GERMANY UNIV FRANKFURT,CTR MORPHOL,NEUROBIOL SECT D-60590 FRANKFURT GERMANY
Titolo Testata:
Cell and tissue research
fascicolo: 3, volume: 286, anno: 1996,
pagine: 315 - 323
SICI:
0302-766X(1996)286:3<315:ROMPAI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESOX-LUCIUS L; ONCORHYNCHUS-MYKISS; PHOTORECEPTOR CELLS; HORIZONTAL CELLS; RAT PINEALOCYTES; TRANSMISSION; RESPONSES; RETINA; PIKE; GABA;
Keywords:
PINEAL ORGAN; MELATONIN; NOREPINEPHRINE; CALCIUM; FURA-2; PHOTORECEPTOR; RAINBOW TROUT, ONCORHYNCHUS MYKISS (TELEOSTEI);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
H. Meissl et al., "REGULATION OF MELATONIN PRODUCTION AND INTRACELLULAR CALCIUM CONCENTRATIONS IN THE TROUT PINEAL ORGAN", Cell and tissue research, 286(3), 1996, pp. 315-323

Abstract

The present in vitro study correlates measurements of the melatonin production from trout pineal organs with those of the intracellular calcium concentration in pinealocytes. Melatonin production increases with decreasing irradiance and shows maximal values in darkness. Some pinealocytes exhibit spontaneous calcium oscillations, although most of them have a stable basal calcium concentration. Diminishing extracellular calcium and enhancing magnesium reduces melatonin release in the light-and dark-adapted state. The application of Co2+ decreases melatonin secretion in the mesopic and scotopic range, reversibly blocks spontaneous calcium oscillations, reduces the basal intracellular calcium concentration in non-oscillating pinealocytes, and inhibits the KCl-induced rise in intracellular calcium. Application of glutamate, norepinephrine, isoproterenol, or dopamine has no significant effect on melatonin secretion. Norepinephrine does not influence the calcium concentration in any of the trout pinealocytes. Treatment with the GABA(A)-receptor agonist muscimol causes a slight I eduction of melatonin release in the mesopic and scotopic range of illumination, without affecting intracellular calcium concentrations. Thus, Co2+ and low calcium/high magnesium buffer reduce melatonin release through an action on the calcium concentration in trout pinealocytes and not through a blockade of synaptic transmission. All the data show that the trout pineal organ synthesizes and releases melatonin in relation to the irradiance of theincident light and that neuronal inputs have a minor, if any, influence on melatonin synthesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 01:24:38