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Titolo:
STRUCTURE AND THERMAL-STABILITY OF ALPRAZOLAM AND SELECTED SOLVATES
Autore:
CAIRA MR; EASTER B; HONIBALL S; HORNE A; NASSIMBENI LR;
Indirizzi:
UNIV CAPE TOWN,DEPT CHEM RONDEBOSCH 7700 SOUTH AFRICA FINE CHEM CORP EPPINDUST 7475 SOUTH AFRICA
Titolo Testata:
Journal of pharmaceutical sciences
fascicolo: 11, volume: 84, anno: 1995,
pagine: 1379 - 1384
SICI:
0022-3549(1995)84:11<1379:SATOAA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CRYSTAL; POLYMORPHISM; EFFICACY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
M.R. Caira et al., "STRUCTURE AND THERMAL-STABILITY OF ALPRAZOLAM AND SELECTED SOLVATES", Journal of pharmaceutical sciences, 84(11), 1995, pp. 1379-1384

Abstract

Five forms of the drug alprazolam have been identified by thermal analysis and X-ray powder diffraction (XRD), The single crystal X-ray structures of two of these species, a polymorph 1 and a dihydrate 2, weredetermined. The dihydrate crystallized from a solution of alprazolam in methanol containing traces of water. Species 3 and 4 are nonstoichiometric solvates with ethanol and acetonitrile, respectively, The differential scanning calorimetric curves for the solvates 2-4 are similar, showing a desolvation endotherm, followed by an exotherm associated with recrystallization, and a final endotherm for the fusion of alprazolam, The solvates 3 and 4 were shown to be isomorphous by XRD, The products of desolvation of 2-4 were identified by their XRD traces, Solvates 2 and 3 yield polymorph 1 on desolvation, whereas solvate 4 yields a different polymorph.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:50:56