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Titolo:
RICIN - MECHANISM OF ACTION, DETECTION, AND INTOXICATION
Autore:
WELLNER RB; HEWETSON JF; POLI MA;
Indirizzi:
USA,MED RES INST INFECT DIS FREDERICK MD 21702
Titolo Testata:
Journal of toxicology. Toxin reviews
fascicolo: 4, volume: 14, anno: 1995,
pagine: 483 - 522
SICI:
0731-3837(1995)14:4<483:R-MOAD>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR-MEDIATED ENDOCYTOSIS; TOXIC PROTEINS ABRIN; HAMSTER OVARY CELLS; TRANS-GOLGI NETWORK; MONOCLONAL-ANTIBODY PROPHYLAXIS; CHAIN-CONTAINING IMMUNOTOXINS; GALACTOSE-BINDING ABILITY; SITE-DIRECTED MUTAGENESIS; LIVER ENDOTHELIAL-CELLS; N-GLYCOSIDASE ACTIVITY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
185
Recensione:
Indirizzi per estratti:
Citazione:
R.B. Wellner et al., "RICIN - MECHANISM OF ACTION, DETECTION, AND INTOXICATION", Journal of toxicology. Toxin reviews, 14(4), 1995, pp. 483-522

Abstract

The many uses of ricin for basic research and clinical studies have made it an intensively studied molecule. Although the exact mechanism by which the toxin kills animals is unknown, ricin kills cells by entering the cytosol and inhibiting protein synthesis. In all areas of clinical use, forensic medicine, and basic scientific inquiry, the capability to detect the toxin is of primary importance. Recent efforts to produce a vaccine originate from a perception that this widely availabletoxic plant protein could be a poor man's weapon of mass destruction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 13:57:54