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Titolo:
INTEREST OF ROUTINE MEASUREMENT OF SERUM CALCITONIN - STUDY IN A LARGE SERIES OF THYROIDECTOMIZED PATIENTS
Autore:
NICCOLI P; WIONBARBOT N; CARON P; HENRY JF; DEMICCO C; SAINTANDRE JP; BIGORNE JC; MODIGLIANI E; CONTDEVOLX B;
Indirizzi:
FAC MED,UNITE 38,BLVD JEAN MOULIN F-13353 MARSEILLE 05 FRANCE CHU TIMONE,SERV ENDOCRINOL MARSEILLE FRANCE CHU TIMONE,SERV CHIRURG ENDOCRINIENNE MARSEILLE FRANCE CHU TIMONE,LAB ANATOMOPATHOL MARSEILLE FRANCE CHU ANGERS,SERV ENDOCRINOL ANGERS FRANCE CHU ANGERS,LAB ANTATOMOPATHOL ANGERS FRANCE CHU RANGUEIL,SERV ENDOCRINOL F-31054 TOULOUSE FRANCE HOP AVICENNE,SERV ENDOCRINOL F-93009 BOBIGNY FRANCE
Titolo Testata:
The Journal of clinical endocrinology and metabolism
fascicolo: 2, volume: 82, anno: 1997,
pagine: 338 - 341
SICI:
0021-972X(1997)82:2<338:IORMOS>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDULLARY-THYROID CARCINOMA; C-CELL HYPERPLASIA; PENTAGASTRIN STIMULATION TEST; MONOCLONAL-ANTIBODIES; RET PROTOONCOGENE; EARLY DIAGNOSIS; ASSAY; TUMORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
P. Niccoli et al., "INTEREST OF ROUTINE MEASUREMENT OF SERUM CALCITONIN - STUDY IN A LARGE SERIES OF THYROIDECTOMIZED PATIENTS", The Journal of clinical endocrinology and metabolism, 82(2), 1997, pp. 338-341

Abstract

The aim of our study was to assess the ability of routine calcitonin (CT) measurement to improve the preoperative diagnosis of medullary thyroid carcinoma (MTC) in nodular thyroid diseases. We systematically determined basal CT in 1167 patients before thyroid surgery and performed a pentagastrin (Pg) CT stimulation test in 121 of these patients whose basal CT level was normal. Sixteen MTC (1.37%) were found on histopathological examination of surgical specimens: 14 in the 34 patients (41.1%) with abnormal basal CT levels and 2 in the 1133 patients with normal basal CT levels (0.17%). An abnormal increase in Pg-stimulated CT was observed in 7 of the 121 patients tested and was related to microscopic MTC in 2 cases. Among 1167 thyroidectomized patients with nodular thyroid diseases, the prevalence of MTC was 1.37% and reached 41.1% when the basal CT level was abnormal (3% of the patients). CT evaluation detected MTC, whereas other procedures, such as fine needle aspiration cytology, failed, thus allowing early radical surgery. CT measurement should thus become a routine part of the diagnostic evaluation of nodular thyroid diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 20:06:52