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Titolo:
A FUNCTIONAL NEUROANATOMY OF HALLUCINATIONS IN SCHIZOPHRENIA
Autore:
SILBERSWEIG DA; STERN E; FRITH C; CAHILL C; HOLMES A; GROOTOONK S; SEAWARD J; MCKENNA P; CHUA SE; SCHNORR L; JONES T; FRACKOWIAK RSJ;
Indirizzi:
HAMMERSMITH HOSP,MRC,CYCLOTRON UNIT,DUCANE RD LONDON W12 0NN ENGLAND HAMMERSMITH HOSP,INST NEUROL,WELLCOME DEPT COGNIT NEUROL LONDON W12 0NN ENGLAND NEW YORK HOSP,CORNELL MED CTR,FUNCT NEUROIMAGING LAB NEW YORK NY 10021 FULBOURNE HOSP FULBOURN CB1 5EF ENGLAND
Titolo Testata:
Nature
fascicolo: 6553, volume: 378, anno: 1995,
pagine: 176 - 179
SICI:
0028-0836(1995)378:6553<176:AFNOHI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; AUDITORY HALLUCINATIONS; AREA; PET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
D.A. Silbersweig et al., "A FUNCTIONAL NEUROANATOMY OF HALLUCINATIONS IN SCHIZOPHRENIA", Nature, 378(6553), 1995, pp. 176-179

Abstract

HALLUCINATIONS, perceptions in the absence of external stimuli, are prominent among the core symptoms of schizophrenia. The neural correlates of these brief, involuntary experiences are not well understood, and have not been imaged selectively. We have used new positron emissiontomography (PET) methods(1,2) to study the brain state associated with the occurrence of hallucinations in six schizophrenic patients. Herewe present a group study of five patients with classic auditory verbal hallucinations despite medication, demonstrating activations in subcortical nuclei (thalamic, striatal), limbic structures (especially hippocampus), and paralimbic regions (parahippocampal and cingulate gyri,as well as orbito-frontal cortex). We also present a case study of a unique, drug-naive patient with visual as well as auditory verbal hallucinations, demonstrating activations in visual and auditory/linguistic association cortices as part of a distributed cortical-subcortical network. Activity in deep brain structures, identified with group analysis, may generate or modulate hallucinations, and the particular neocortical regions entrained in individual patients may affect their specific perceptual content. The interaction of these distributed neural systems provides a biological basis for the bizarre reports of schizophrenic patients.

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Documento generato il 22/01/20 alle ore 18:26:35