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Titolo:
EFFECTS OF ERGOTAMINE AND DIHYDROERGOTAMINE ON 5-HYDROXYTRYPTAMINE-2ARECEPTORS IN THE ISOLATED RAT AORTA
Autore:
KALKMAN HO; SCHNEIDER F;
Indirizzi:
SANDOZ PHARMA LTD,PRECLIN RES,BLDG 360-405 CH-4002 BASEL SWITZERLAND
Titolo Testata:
Pharmacology
fascicolo: 6, volume: 53, anno: 1996,
pagine: 351 - 355
SICI:
0031-7012(1996)53:6<351:EOEADO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-ADRENOCEPTORS; 5-HT1-LIKE RECEPTOR; INHIBITION; RELAXATION; KETANSERIN; ACTIVATION; RESPONSES; VEINS; ILEUM; DOG;
Keywords:
DIHYDROERGOTAMINE; ERGOTAMINE; RAT AORTA; KETANSERIN; 5-HYDROXYTRYPTAMINE RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
H.O. Kalkman e F. Schneider, "EFFECTS OF ERGOTAMINE AND DIHYDROERGOTAMINE ON 5-HYDROXYTRYPTAMINE-2ARECEPTORS IN THE ISOLATED RAT AORTA", Pharmacology, 53(6), 1996, pp. 351-355

Abstract

Ergotamine contracted isolated rat aorta rings with an intrinsic activity of 50% of that of 5-hydroxytryptamine (5-HT, 0.1 mmol/l). Dihydroergotamine did not contract the tissue, but insurmountably blocked contraction in response to ergotamine and 5-HT. The 5-HT2A receptor antagonist, ketanserin (0.1 mu mol/l), inhibited ergotamine (pK(B) 8.0) and5-HT (pK(B) 8.1) induced contractions. These results indicate that inthe rat aorta ergotamine is a partial 5-HT2A receptor agonist, whilstdihydroergotamine is an insurmountable 5-HT2A receptor antagonist. The present data could explain why ergotamine displays more cardiovascular and uterotonic side effects than dihydroergotamine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 13:16:45