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Titolo:
FAS INVOLVEMENT IN HUMAN NK CELL APOPTOSIS - LACK OF A REQUIREMENT FOR CD16-MEDIATED EVENTS
Autore:
ORTALDO JR; WINKLERPICKETT RT; NAGATA S; WARE CF;
Indirizzi:
NCI,FREDERICK CANC RES & DEV CTR,LEI,DIV BASIC SCI,BLDG 560,RM 31-93 FREDERICK MD 21702 UNIV CALIF RIVERSIDE,DIV BIOMED SCI RIVERSIDE CA 92521 OSAKA BIOSCI INST OSAKA JAPAN
Titolo Testata:
Journal of leukocyte biology
fascicolo: 2, volume: 61, anno: 1997,
pagine: 209 - 215
SICI:
0741-5400(1997)61:2<209:FIIHNC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; LARGE GRANULAR LYMPHOCYTES; T-LYMPHOCYTES; PERIPHERAL-BLOOD; TRIGGERING MOLECULE; DEATH FACTOR; ANTIGEN; EXPRESSION; LIGAND; ACTIVATION;
Keywords:
CYTOKINES; CROSS-LINKING; FC-GAMMA-RIII RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
J.R. Ortaldo et al., "FAS INVOLVEMENT IN HUMAN NK CELL APOPTOSIS - LACK OF A REQUIREMENT FOR CD16-MEDIATED EVENTS", Journal of leukocyte biology, 61(2), 1997, pp. 209-215

Abstract

Propriocidal regulation of T cells refers to apoptosis induced by interleukin-2 (IL-2) activation with subsequent antigen receptor stimulation, We previously reported that natural killer (NK) cells also exhibit propriocidal death. Cell death can be induced following occupancy ofthe Fc gamma RIII (CD16) receptor when NK cells were pretreated with IL-2, IL-12, or IL-15, Here we show other triggering receptors on NK cells such as CD44, anti-NK-receptor antibodies, and pharmacological activation can result in the cell death signal. Requirement for cell interactions indicated that cell contact was required; however, unlike cell-mediated lysis, extracellular calcium was not required. Like T cells, the process of cell death for NK cells was receptor-induced apoptosis. Activation-induced apoptosis of T cells is mediated by members of the tumor necrosis factor (TNF) cytokine superfamily. We examined the involvement of TNF receptor family members or Fas in this rapid cell death, Antibody directed against Fas, TNFR(60), TNFR(80), LTBR, and LT alpha failed to inhibit receptor-induced death. Therefore, NK cells appear to demonstrate a rapid apoptotic episode when CD16 is cross-linked, but the mechanism of this apoptosis is quite different than was observed in T cells with CD3. The direct examination of the Fas pathway on activated NK cells revealed that susceptibility required longer treatment times and IL-2 activation. This susceptibility was paralleled byincreased Fas-ligand expression. Therefore, NK cells can demonstrate an apoptotic response to CD16, CD44, NK receptors, and Fas. The enumeration of ligands capable of eliciting NK cell death and the in vivo relevance of this observation require further study.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 14:35:09