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Titolo:
STEREOCHEMICAL PREFERENCES AND REQUIREMENT FOR THE 3-HYDROXYL GROUP IN NOVEL ANTICONVULSANT 4-FLUOROBENZOYLAMINO BENZOPYRANS
Autore:
BROWN TH; CAMPBELL CA; CHAN WN; EVANS JM; MARTIN RT; STEAN TO; STEMP G; STEVENS NC; THOMPSON M; UPTON N; VONG AK;
Indirizzi:
SMITHKLINE BEECHAM PHARMACEUT,NEW FRONTIERS SCI PK,3RD AVE HARLOW CM19 5AW ESSEX ENGLAND SMITHKLINE BEECHAM PHARMACEUT HARLOW CM19 5AW ESSEX ENGLAND
Titolo Testata:
Bioorganic & medicinal chemistry letters
fascicolo: 21, volume: 5, anno: 1995,
pagine: 2563 - 2566
SICI:
0960-894X(1995)5:21<2563:SPARFT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
5
Recensione:
Indirizzi per estratti:
Citazione:
T.H. Brown et al., "STEREOCHEMICAL PREFERENCES AND REQUIREMENT FOR THE 3-HYDROXYL GROUP IN NOVEL ANTICONVULSANT 4-FLUOROBENZOYLAMINO BENZOPYRANS", Bioorganic & medicinal chemistry letters, 5(21), 1995, pp. 2563-2566

Abstract

A cis 3S,4S isomer, derived stereospecifically from an anticonvulsanttrans 3R,4S-(para-fluorobenzoylamino)-benzopyran using the DAST reagent, has been shown to possess anticonvulsant properties. In contrast the cis 3R,4R enantiomer did not possess anticonvulsant properties but caused blood pressure to fall.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:18:22