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Titolo:
THE SYNTHESIS OF PYRAZOLO[4,3-C]-ARYL[E]FUSED AND IMIDAZO[4,5-C]-ARYL[E]FUSED PYRIDINES AS STRUCTURAL ANALOGS OF 4-AMINONICOTINOATES
Autore:
BENHAM CD; BLACKBURN TP; JOHNS A; KOTECHA NR; MARTIN RT; THOMAS DR; THOMPSON M; WARD RW;
Indirizzi:
SMITHKLINE BEECHAM PHARMACEUT,NEW FRONTIERS SCI PK,3RD AVE HARLOW CM19 5AW ESSEX ENGLAND SMITHKLINE BEECHAM PHARMACEUT HARLOW CM19 5AW ESSEX ENGLAND
Titolo Testata:
Bioorganic & medicinal chemistry letters
fascicolo: 21, volume: 5, anno: 1995,
pagine: 2455 - 2460
SICI:
0960-894X(1995)5:21<2455:TSOPAI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC ACID; BINDING; AGENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
C.D. Benham et al., "THE SYNTHESIS OF PYRAZOLO[4,3-C]-ARYL[E]FUSED AND IMIDAZO[4,5-C]-ARYL[E]FUSED PYRIDINES AS STRUCTURAL ANALOGS OF 4-AMINONICOTINOATES", Bioorganic & medicinal chemistry letters, 5(21), 1995, pp. 2455-2460

Abstract

A series of 4-aminobenzothienopyridine-3-carboxylates 4 to 10 has been prepared and the SAR of these GABA(A) modulators discussed, Replacement of the 4-aminonicotinoate moiety by imidazo [4,5-c] ring fusion provides potent bioisosteres 12 to 14.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:48:31