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Titolo:
CLOMIPRAMINE TREATMENT FOR STEREOTYPY AND RELATED REPETITIVE MOVEMENT-DISORDERS ASSOCIATED WITH MENTAL-RETARDATION
Autore:
LEWIS MH; BODFISH JW; POWELL SB; GOLDEN RN;
Indirizzi:
UNIV FLORIDA,DEPT PSYCHIAT,POB 100256 GAINESVILLE FL 32610 WESTERN CAROLINA CTR MORGANTON NC 00000 UNIV N CAROLINA CHAPEL HILL NC 00000
Titolo Testata:
American journal of mental retardation
fascicolo: 3, volume: 100, anno: 1995,
pagine: 299 - 312
SICI:
0895-8017(1995)100:3<299:CTFSAR>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMMUNITY RESIDENTIAL FACILITIES; OBSESSIVE-COMPULSIVE DISORDER; ABERRANT BEHAVIOR CHECKLIST; FLUOXETINE TREATMENT; AUTISTIC DISORDER; RETARDED PATIENTS; RATING-SCALE; SELF-INJURY; EFFICACY; ADULTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
M.H. Lewis et al., "CLOMIPRAMINE TREATMENT FOR STEREOTYPY AND RELATED REPETITIVE MOVEMENT-DISORDERS ASSOCIATED WITH MENTAL-RETARDATION", American journal of mental retardation, 100(3), 1995, pp. 299-312

Abstract

The efficacy of the serotonin uptake inhibitor clomipramine in the treatment of stereotyped and related repetitive behavior disorders was tested in individuals with severe and profound mental retardation. A double-blind, placebo-controlled crossover trial of clomipramine was associated with significant reductions in the frequency and intensity of stereotyped behavior and teacher ratings of stereotypy, hyperactivity,and irritability as well as increased adaptive engagement and decreased staff intervention for nontargeted behavior problems. Adverse effects occurred in 3 of the 10 subjects. Of the 7 subjects who tolerated the drug, 6 exhibited a clinically significant improvement in one or more repetitive behaviors. Our results provide support for the hypothesis that clomipramine is effective in treating stereotyped and related behaviors associated with mental retardation.

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Documento generato il 25/09/20 alle ore 10:13:13