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Titolo:
METAMORPHIC REMODELING OF THE PRIMARY OLFACTORY PROJECTION IN XENOPUS- DEVELOPMENTAL INDEPENDENCE OF PROJECTIONS FROM OLFACTORY NEURON SUBCLASSES
Autore:
REISS JO; BURD GD;
Indirizzi:
UNIV ARIZONA,DEPT MOL & CELLULAR BIOL,LSS 444 TUCSON AZ 85721 UNIV ARIZONA,DEPT MOL & CELLULAR BIOL TUCSON AZ 85721
Titolo Testata:
Journal of neurobiology
fascicolo: 2, volume: 32, anno: 1997,
pagine: 213 - 222
SICI:
0022-3034(1997)32:2<213:MROTPO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ODORANT RECEPTOR EXPRESSION; SOYBEAN AGGLUTININ; MOLECULAR-BASIS; EPITHELIUM; SYSTEM; BULB; TOPOGRAPHY; RAT; ORGANIZATION; INFORMATION;
Keywords:
XENOPUS; OLFACTORY NEURON; OLFACTORY BULB; TOPOGRAPHIC MAPPING; DEVELOPMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
J.O. Reiss e G.D. Burd, "METAMORPHIC REMODELING OF THE PRIMARY OLFACTORY PROJECTION IN XENOPUS- DEVELOPMENTAL INDEPENDENCE OF PROJECTIONS FROM OLFACTORY NEURON SUBCLASSES", Journal of neurobiology, 32(2), 1997, pp. 213-222

Abstract

In adult Xenopus, the nasal cavity is divided into separate middle (MC) and principal (PC) cavities; the former is used to smell water-borne odorants, the latter air-borne odorants. Recent work has shown that olfactory neurons of each cavity express a distinct subclass of odorant receptors. Moreover, MC and PC axons project to distinct regions of the olfactory bulb. To examine the developmental basis for this specificity in the olfactory projection, we extirpated the developing MC from early metamorphic (stage 54-57) tadpoles and raised the animals through metamorphosis. In most lesioned animals, the MC partly regenerated. Compared with the unlesioned side, reduction of the region of the glomerular layer of the olfactory bulb receiving MC afferents ranged from 70% to 95%. PC afferents did not occupy regions of the olfactory bulb deprived of MC afferents. These results support a model in which intrinsic cues in the olfactory bulb control the projection pattern attained by ingrowing olfactory axons. (C) 1997 John Wiley & Sons, Inc.

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Documento generato il 07/08/20 alle ore 00:48:12