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Titolo:
NITRIC-OXIDE SYNTHETIC PATHWAY AND REGULATION - ITS POTENTIAL ROLE INIMMUNE AND INFLAMMATORY REACTIONS IN THE GLOMERULUS
Autore:
COOK HT; CATTELL V;
Indirizzi:
ST MARYS HOSP,SCH MED,DEPT HISTOPATHOL,NORFOLK PL LONDON W2 1PG ENGLAND
Titolo Testata:
JN. Journal of nephrology
fascicolo: 5, volume: 8, anno: 1995,
pagine: 247 - 254
SICI:
1121-8428(1995)8:5<247:NSPAR->2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Keywords:
NITRIC OXIDE; GLOMERULONEPHRITIS; MESANGIUM; L-ARGININE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
H.T. Cook e V. Cattell, "NITRIC-OXIDE SYNTHETIC PATHWAY AND REGULATION - ITS POTENTIAL ROLE INIMMUNE AND INFLAMMATORY REACTIONS IN THE GLOMERULUS", JN. Journal of nephrology, 8(5), 1995, pp. 247-254

Abstract

Nitric oxide (NO) is a free radical synthesised by nitric oxide synthase from L-arginine by a family of nitric oxide synthase (NOS) enzymes. It is involved in vasodilatation, neurotransmission and is a mediator of macrophage cytotoxicity. One of the isoforms of NOS (iNOS) is induced in a wide range of cells by inflammatory cytokines and may synthesise large quantities of NO over many hours. There is strong evidence for the involvement of NO in glomerulonephritis. Isolated nephritic glomeruli synthesise nitrite, the stable end product of NO, and iNOS mRNA and protein are present. Infiltrating macrophages are a major sourceof glomerular NO but mesangial cells also possess an inducible iNOS. The role of this versatile molecule in glomerulonephritis remains to be clarified with evidence both for a beneficial role, possibly throughimprovement in glomerular blood flow and scavenging superoxide anion,and for a harmful effect possibly by direct toxicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 12:56:55